Evidence map›Paper›PMID 42219425›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2026

Integration of TSPO PET and fluid biomarkers to assess neuroinflammation in Parkinson's disease.

Skye Hsin-Hsien Yeh, Tsung-Hsun Yu, Chia-Ju Liu, Sung-Pin Fan, Pin-Shiuan Chen, Cheng-Hsuan Li, Mei-Fang Cheng, Chin-Hsien Lin

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Article in European journal of nuclear medicine and molecular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

8 authors.

Skye Hsin-Hsien YehSchool of Medicine, National Defense Medical University, Taipei, Taiwan.
Tsung-Hsun YuSchool of Medicine, National Defense Medical University, Taipei, Taiwan.
Chia-Ju LiuDepartment of Nuclear Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan.
Sung-Pin FanDepartment of Neurology, National Taiwan University Hospital, Taipei 100, Taipei, Taiwan.
Pin-Shiuan ChenDepartment of Neurology, National Taiwan University Hospital, Taipei 100, Taipei, Taiwan.
Cheng-Hsuan LiDepartment of Neurology, National Taiwan University Hospital, Taipei 100, Taipei, Taiwan.
Mei-Fang Cheng *Department of Nuclear Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan. meifang@ntuh.gov.tw.ORCID 0000-0002-9359-0606
Chin-Hsien Lin *Department of Neurology, National Taiwan University Hospital, Taipei 100, Taipei, Taiwan. chlin@ntu.edu.tw.

Funding

National Science and Technology Council 114-2314-B-016 -018 -MY3National Taiwan University Hospital NTUH114-S0032
6 · The paper itself

Abstract

purposeMicroglia-mediated neuroinflammation is implicated in Parkinson's disease (PD), but its relationship with clinical severity remains controversial. Using [

methodsNinety participants (71 patients with PD and 19 age-matched controls) underwent TSPO PET and plasma measurements of soluble triggering receptor expression on myeloid cells-2 (sTREM2), glial fibrillary acidic protein (GFAP), and neurofilament light chain (NfL). Binding potential relative to the non-displaceable compartment (BP

resultsPatients with PD had higher TSPO BP

conclusionTSPO PET with plasma biomarkers revealed region-specific neuroinflammation associated with motor and cognitive severity in Parkinson's disease progression.

Indexed as

Neuroinflammatory DiseasesParkinson DiseasePositron-Emission TomographyReceptors, GABAAgedBiomarkersFemaleHumansMaleMembrane GlycoproteinsMiddle AgedReceptors, ImmunologicBiomarkersMembrane GlycoproteinsReceptors, GABAReceptors, ImmunologicTREM2 protein, humanTSPO protein, humanDementiaNeuroinflammationParkinson’s diseaseTSPO

Identifiers

PMID42219425
PMCPMC13526108

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.