ReviewJournal of physiology and biochemistry2026
Dietary bioactive compounds modulating satiety and appetite: mechanisms of action.
Review in Journal of physiology and biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
12 authors.
Funding
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Abstract
Obesity and overweight represent critical public health problems worldwide, driving the search for effective strategies for their prevention and treatment. Modulating appetite and satiety through natural compounds present in the diet emerges as a promising approach to controlling energy intake and improving metabolic balance. This article reviews the molecular and physiological mechanisms involved in appetite regulation, including the function of gastrointestinal hormones (GLP-1, CCK, PYY, ghrelin), the role of the hypothalamus, and the influence of microbial metabolites such as short-chain fatty acids (SCFAs). Different groups of compounds such as fibres, proteins, lipids, polyphenols, saponins, and alkaloids are analyzed in relation to their capacity to modulate both orexigenic (ghrelin) and anorexigenic signals (GLP-1, CCK, PYY), as well as their broader effects on neuroendocrine and metabolic pathways. Despite the growing body of preclinical evidence, results in humans are still limited and, at times, inconsistent, underscoring the need for long-term controlled studies to clarify their mechanisms and clinical potential. This review provides a comprehensive overview of the pathways through which dietary bioactive compounds can contribute to appetite regulation, providing a scientific basis for the development of nutritional interventions aimed at combating obesity and related metabolic disorders.
Indexed as
Identifiers
42219442What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.