Evidence map›Paper›PMID 42219899›Full record

ArticleJournal of diabetes research2026

Grape Exosome-Like Nanovesicles Reverse the Prediabetic State in Mice.

Zao-Ling Liu, Shu-Ya Cai, Aerna Qiayimaerdan, Zulipia Zunon, Ya-Le Yu, Xiao-Die Ma

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zao-Ling LiuSchool of Public Health, Xinjiang Medical University, Urumqi, China, xjmu.edu.cn.ORCID https://orcid.org/0000-0002-5994-2612
Shu-Ya CaiSchool of Public Health, Xinjiang Medical University, Urumqi, China, xjmu.edu.cn.
Aerna QiayimaerdanSchool of Public Health, Xinjiang Medical University, Urumqi, China, xjmu.edu.cn.
Zulipia ZunonSchool of Public Health, Xinjiang Medical University, Urumqi, China, xjmu.edu.cn.
Ya-Le YuSchool of Public Health, Xinjiang Medical University, Urumqi, China, xjmu.edu.cn.
Xiao-Die MaSchool of Public Health, Xinjiang Medical University, Urumqi, China, xjmu.edu.cn.

Funding

National Natural Science Foundation of China 82160605Xinjiang Uyghur Autonomous Region's 14th Five-Year Plan for Characteristic Disciplines in Public Health and Preventive Medicine in Higher Education
6 · The paper itself

Abstract

objectiveThis research explored the effect of grape exosome-like nanovesicles (GELNs) on reversing prediabetic conditions in mice and investigated the underlying mechanisms via metabolomic and gut microbiota analyses.

methodsTwenty-four C57BL/6J mice were divided into four groups: normal control, prediabetic model, GELN intervention, and nutrient intervention. Prediabetic models were induced in all but the control group, and then the intervention groups were treated for 8 weeks.

resultsGELNs significantly improved fasting blood glucose, 2-h postprandial glucose, insulin levels, and total cholesterol. Metabolomic analysis found enriched differential metabolites, highlighting tryptophan and riboflavin metabolism. 16S rDNA sequencing showed no difference in α-diversity but differences in β-diversity. At the phylum level, the abundance of Firmicutes and Desulfobacterota was higher in the GELN group (Group W), while Bacteroidota and Proteobacteria were more abundant in the model group (Group T). At the genus level, Akkermansia was significantly reduced in the GELN group (Group W), indicating a notable shift in gut microbiota composition.

conclusionGELNs may reverse prediabetes in mice by improving metabolic health and gut homeostasis, offering new insights for prediabetes prevention and treatment.

Indexed as

ExosomesGastrointestinal MicrobiomePrediabetic StateVitisAnimalsBlood GlucoseCholesterolDisease Models, AnimalInsulinMaleMetabolomicsMiceMice, Inbred C57BLBlood GlucoseCholesterolInsulingrape exosome–like nanovesiclesgut microbiotanontargeted metabolomicsprediabetes

Identifiers

PMID42219899
PMCPMC13239045

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.