Evidence map›Paper›PMID 42219935›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2026

Mechanically Programmable DNA Hydrogel Microparticles for 3D Cellular Systems.

Tobias Walther, Eleni Dalaka, Gotthold Fläschner, Manuel Gómez-González, Ilia Platzman, Sadaf Pashapour, Michelle Emmert, Pere Roca-Cusachs, Xavier Trepat, Kerstin Göpfrich

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tobias WaltherCenter for Molecular Biology of Heidelberg University (ZMBH), Biophysical Engineering Group, Heidelberg University, Heidelberg, Germany.ORCID 0000-0003-1397-6777
Eleni DalakaInstitute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
Gotthold FläschnerInstitute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
Manuel Gómez-GonzálezInstitute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
Ilia PlatzmanDepartment of Cellular Biophysics, Max Planck Institute for Medical Research, Heidelberg, Germany.ORCID 0000-0003-1239-7458
Sadaf PashapourInstitute for Molecular Systems Engineering and Advanced Materials (IMSEAM), Heidelberg University, Heidelberg, Germany.ORCID 0000-0002-9925-7521
Michelle EmmertCenter for Molecular Biology of Heidelberg University (ZMBH), Biophysical Engineering Group, Heidelberg University, Heidelberg, Germany.
Pere Roca-CusachsInstitute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.ORCID 0000-0001-6947-961X
Xavier TrepatInstitute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.ORCID 0000-0002-7621-5214
Kerstin GöpfrichCenter for Molecular Biology of Heidelberg University (ZMBH), Biophysical Engineering Group, Heidelberg University, Heidelberg, Germany.

Funding

Departament de Salut, Generalitat de CatalunyaDeutsche Forschungsgemeinschaft EXC-2082/1 - 390761711Deutsche Forschungsgemeinschaft EXC-3018/1-533587280Fundación Española para la Ciencia y la TecnologíaH2020 European Research Council Adv-101097753H2020 European Research Council Adv-883739HORIZON EUROPE European Research Council 101076997HORIZON EUROPE Marie Sklodowska-Curie Actions 101206469Human Frontiers Science Program RGPO03I2023Studienstiftung des Deutschen Volkes
6 · The paper itself

Abstract

Hydrogel microparticles (HMPs) are powerful tools to study and manipulate cellular behavior in 3D cell culture systems and animal models. Here, fully DNA-based HMPs are presented, whose material properties can be precisely tuned by sequence-programmable design of self-assembling DNA nanostructures. These DNA-HMPs offer control over size, stiffness, viscoelasticity and ligand presentation. They are formed by microfluidic encapsulation of two types of orthogonal DNA nanostars and a sequence-complementary DNA linker in water-in-oil droplets. By varying the valency of the DNA nanostar designs, tunable mechanical properties are achieved - spanning three orders of magnitude in Young's modulus from

Indexed as

DNAHydrogelsMechanical PhenomenaAnimalsDNA NanostructuresElastic ModulusFibroblastsMiceOligopeptidesSpheroids, CellularViscosityarginyl-glycyl-aspartic acidDNAHydrogelsOligopeptides3D cell culturebiomaterialsDNA hydrogelDNA nanotechnologyhydrogel microparticlesmechanobiologymicrofluidics

Identifiers

PMID42219935
PMCPMC13327248

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.