Evidence map›Paper›PMID 42219970›Full record

ArticleRenal failure2026

Polydatin alleviates adenine-induced nephropathy in mice.

Tao Sheng, Tianhong Ma, Xin Jin, Debin Chen, Shipeng Che, Jie Wang, Jiadu Shen, Chaoqun Shi, Qiang Li, Yixin Sun and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Renal failure, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tao ShengDepartment of Urology, Jiaxing University Affiliated TCM Hospital, Jiaxing, P. R. China.
Tianhong MaDepartment of Pharmacy, Jiaxing University Affiliated TCM Hospital, Jiaxing, P. R. China.
Xin JinDepartment of Pathology and Forensic Medicine, Institute of Forensic Science, Jiaxing University, Jiaxing, P. R. China.
Debin ChenJiaxing Yiheyuan Xiangjiadang Rehabilitation and Nursing Hospital, Jiaxing, P. R. China.
Shipeng CheDepartment of Pathology and Forensic Medicine, Institute of Forensic Science, Jiaxing University, Jiaxing, P. R. China.
Jie WangDepartment of Pathology and Forensic Medicine, Institute of Forensic Science, Jiaxing University, Jiaxing, P. R. China.
Jiadu ShenDepartment of Pathology and Forensic Medicine, Institute of Forensic Science, Jiaxing University, Jiaxing, P. R. China.
Chaoqun ShiDepartment of Pathology and Forensic Medicine, Institute of Forensic Science, Jiaxing University, Jiaxing, P. R. China.
Qiang LiDepartment of Pathology and Forensic Medicine, Institute of Forensic Science, Jiaxing University, Jiaxing, P. R. China.
Yixin SunDepartment of Pathology and Forensic Medicine, Institute of Forensic Science, Jiaxing University, Jiaxing, P. R. China.
Deqing ChenDepartment of Pathology and Forensic Medicine, Institute of Forensic Science, Jiaxing University, Jiaxing, P. R. China.
Guangtao XuDepartment of Pathology and Forensic Medicine, Institute of Forensic Science, Jiaxing University, Jiaxing, P. R. China.ORCID 0000-0001-5846-9280

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAdenine-induced nephropathy (AIN) serves as a classic experimental model for studying uric acid-related renal injury, characterized by tubular obstruction, inflammatory cell infiltration, tubular epithelial cell apoptosis, and progressive interstitial fibrosis, among others. These pathological changes are primarily driven by intrarenal deposition of adenine metabolites, and the model reliably recapitulates both hyperuricemia and impaired renal function. The aim of this study was to assess the renoprotective potential of polydatin (PD) in a murine model of AIN.

methodsFifty male mice (weight, 20 ± 2 g) obtained from The Institute of Cancer Research were randomly assigned into five groups (

resultsThe outcomes of the present study revealed that renal function and renal histopathology in mice were significantly abnormal in the AIN group. After treatment with PD, it was observed that these abnormal indices were significantly improved, and the structure and function of renal histopathology were significantly protected.

conclusionsPD exhibited a significant therapeutic effect in mice with AIN, which may play a role in protecting the kidneys by regulating various biological processes such as immune inflammation, apoptosis, and fibrosis, providing an important experimental basis and theoretical basis for the clinical use of PD in treating AIN.

Indexed as

GlucosidesKidneyKidney DiseasesStilbenesAdenineAnimalsApoptosisDisease Models, AnimalFibrosisMaleMiceOxidative StressAdenineGlucosidespolydatinStilbenesadenine-induced nephropathy (AIN)micenephropathyPolydatin (PD)renal

Identifiers

PMID42219970
PMCPMC13228186

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.