ArticleJournal of oral & facial pain and headache2026
Identifying neural oscillation and phase synchronization abnormalities in migraine and their predictive values in transcranial magnetic stimulation.
Article in Journal of oral & facial pain and headache, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundMigraine is a prevalent neurological disorder that may substantially disrupt daily function. Repetitive transcranial magnetic stimulation (rTMS) has been shown to be a promising treatment for migraine, but its treatment efficacy still needs to be optimised. This study aimed to identify abnormal neural oscillations in patients with migraines and evaluate their predictive value for TMS treatments to obtain insights for the optimisation of rTMS paradigms.
methodsPatients with migraine received a course of rTMS delivered over the left dorsolateral prefrontal cortex (DLPFC). Resting-state electroencephalography (EEG) was assessed at baseline in both patients with migraine and age- and sex-matched healthy controls.
resultsCompared with healthy controls, patients with migraine were characterised by a slower peak alpha frequency (PAF). In addition, patients with migraine demonstrated alpha-band hyperconnectivity between parieto-occipital regions and between fronto-occipital areas. More importantly, parieto-occipital connectivity showed predictive value for rTMS analgesic effects in this population.
conclusionsThese findings support the potential utility of oscillatory biomarkers for optimising rTMS treatment in patients with migraine. CLINICAL
trial registrationChinese Clinical Trials Registry (ChiCTR2200060337).
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