ReviewFrontiers in immunology2026
Psoriasis as a systemic inflammatory disease: an immune set-point framework for comorbidities and relapse.
Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Psoriasis is increasingly recognized as a systemic immune-mediated disorder that extends beyond cutaneous inflammation. Although skin lesions are its most visible manifestation, growing evidence indicates that psoriasis reflects a broader disruption of immune homeostasis accompanied by sustained systemic inflammatory activation. Persistent immune activation, altered myeloid programming, and dysregulated immunometabolic pathways together establish a state of chronic inflammatory priming. This systemic inflammatory state contributes to multi-organ comorbidities and also favors disease relapse through durable immune memory and trained immunity. In this review, we propose that psoriasis reflects maladaptive reprogramming of the systemic immune set-point, such that both spatial multi-organ involvement and temporal disease recurrence arise from shared immunologic mechanisms. Viewing psoriasis in these terms has important implications for comorbidity assessment, long-term maintenance strategies, and the pursuit of disease modification.
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