Evidence map›Paper›PMID 42220964›Full record

ArticleWorld journal of clinical pediatrics2026

Study on intravenous immunoglobulin use in a pediatric intensive care unit of a tertiary care center.

Poovazhagi Varadarajan, Seenivasan Subramani, Vasanth Jeyaram, Lakshmi S Velmurugan, Raghul Jayaseelan, Gomathy Srividya Venugopal

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In one paragraph

Article in World journal of clinical pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Poovazhagi VaradarajanDepartment of Pediatric Intensive Care, Institute of Child Health and Hospital for Children, Madras Medical College, Chennai 600008, Tamil Nādu, India.
Seenivasan SubramaniDepartment of Pediatric Intensive Care, Institute of Child Health and Hospital for Children, Madras Medical College, Chennai 600008, Tamil Nādu, India. seeni.sholing@gmail.com.
Vasanth JeyaramDepartment of Pediatric Intensive Care, Institute of Child Health and Hospital for Children, Madras Medical College, Chennai 600008, Tamil Nādu, India.
Lakshmi S VelmuruganDepartment of Pediatric Intensive Care, Institute of Child Health and Hospital for Children, Madras Medical College, Chennai 600008, Tamil Nādu, India.
Raghul JayaseelanDepartment of Pediatric Intensive Care, Institute of Child Health and Hospital for Children, Madras Medical College, Chennai 600008, Tamil Nādu, India.
Gomathy Srividya VenugopalDepartment of Pediatric Intensive Care, Institute of Child Health and Hospital for Children, Madras Medical College, Chennai 600008, Tamil Nādu, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIntravenous immunoglobulin (IVIG), an immunomodulatory therapy/agent has been increasingly used and its off label use is on the rise in critical care units. We planned to analyze the indications of IVIG in different disease conditions in pediatric intensive care unit (PICU). This is a single- center ambispective audit on IVIG use.

aimTo study the usage pattern of IVIG among children admitted at a pediatric tertiary care unit.

methodsThis was an ambispective study in which data was collected retrospectively from January 2021 to February 2025 and prospectively from March 2025 to November 2025 in a PICU of a tertiary care center. Details of age, sex, indications, strength of recommendation and survival in each disease group were documented.

resultsFour hundred and fifty five children received IVIG during the study period. The commonest indication was immunological diseases (42.4%,

conclusionIVIG was commonly used in immunological and neurological diseases in our cohort. 78.5% received IVIG as per strength of recommendation A, B, C. Off label use was 21.5%.

Indexed as

Intravenous immunoglobulinLevel of evidenceOff label usePediatric intensive care unitStrength of recommendation

Identifiers

PMID42220964
PMCPMC13220219

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.