ArticleFrontiers in medicine2026
Microbiological eradication of XDR
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
6 authors.
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Abstract
Background: The management of extensively drug-resistant (XDR) Case presentation: We report the case of a 63-year-old male with Stage IV rectal squamous cell carcinoma and Kennedy's disease (spinal and bulbar muscular atrophy) who developed concurrent pulmonary and intra-abdominal infections with CRAB and carbapenem-resistant Results: Microbiological cure was achieved within 14 days, confirmed by the sterilization of both bronchoalveolar lavage fluid and peritoneal drainage cultures. Despite successful source control and infection eradication, the patient could not be weaned from mechanical ventilation. The convergence of critical illness polyneuropathy/myopathy (CIP/CIM), pre-existing neuromuscular degeneration, and malignant cachexia resulted in fatal multiple organ dysfunction syndrome. Conclusion: This case suggests the potential utility of sulbactam-durlobactam in combination with a carbapenem for complicated intra-abdominal infection (cIAI) caused by CRAB, highlighting a successful microbiological outcome. However, it also underscores that microbiological eradication does not invariably translate to clinical survival when overwhelming host factors and irreversible comorbidities dictate the ultimate prognosis.
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