Evidence map›Paper›PMID 42221147›Full record

ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2026

Association of Euthyroid Thyroid Hormone Levels with Hepatic Steatosis in Patients with Nonalcoholic Fatty Liver Disease.

Alihan Oral, Betül Çavuşoğlu Türker, Ender Anılır, Tolga Şahin, Erdem Koçak, Fatih Türker

Abstract read
In one paragraph

Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Alihan OralDepartment of Internal Medicine, Biruni University, İstanbul, Turkey.ORCID 0000-0003-1160-9340
Betül Çavuşoğlu TürkerDepartment of Internal Medicine, Haseki Health Training and Research Hospital, University of Health Sciences Turkey, İstanbul, Turkey.
Ender AnılırDepartment of General Surgery, Ödemis State Hospital, İzmir, Turkey.ORCID 0000-0002-0024-1790
Tolga ŞahinDepartment of Gastroenterology, Bayındır Içerenköy Hospital, İstanbul, Turkey.ORCID 0000-0003-1569-4941
Erdem KoçakDepartment of Internal Medicine, Istınye University, İstanbul, Turkey.
Fatih TürkerDepartment of Internal Medicine, Haseki Health Training and Research Hospital, University of Health Sciences Turkey, İstanbul, Turkey.ORCID 0000-0002-8281-0319

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: The frequency of nonalcolic fatty liver disease (NAFLD), a major health issue that affects people all over the world, has been rising recently. Numerous studies have demonstrated the tight connection between NAFLD and thyroid function. In this study, we aimed to evaluate the relationship between thyroid function tests and the degree of liver steatosis in patients with biopsy proven NAFLD. Patients and Methods: We retrospectively evaluated data of living donor applicants who received liver biopsies. Three hundred sixty seven patients were included in the study. According to the liver biopsy results, the patients were divided into two groups; 227 patients biopsy-proven NAFLD and 145 control subjects without NAFLD. Demographic, anthropometric and laboratory parameters were compared between two groups. Results: All groups thyroid function tests fall within the normal range. However, in patients with NAFLD, serum FT3 and FT4 levels were significantly higher than control group. In addition negative relationship was found between the levels of FT3, FT4, and the stage of NAFLD. In patients with NAFLD, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, triglyceride, total cholesterol levels, homeostasis model assessment of insulin resistance (HOMA-IR), body mass index were significantly high. Conclusion: In this retrospective study, we showed that in patients with NAFLD, serum FT3 and FT4 levels were significantly lower than the control group. Our findings support that low levels of serum FT3 and FT4 might be a risk factor for liver steatosis in euthyroid patients with NAFLD.

Indexed as

hepatic steatosisnonalcolic fatty liver diseasethyroid function

Identifiers

PMID42221147
PMCPMC13217432

What Socratic holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.