Evidence map›Paper›PMID 42221748›Full record

ArticleOpen life sciences2026

Sodium pyruvate attenuates oxidative stress, lowers ox-LDL and ox-LDL/LDL-P, and mitigates inflammation in diabetic atherosclerotic rats.

Ahlam Mohamed Yusuf, Xiehui Chen, Minmin Weng, Zhenzhen Su, Wei Hu, Nan Wu, Jing Xu, Binsheng Chen, Lishan Wu, Wei Sun and 2 more

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In one paragraph

Article in Open life sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ahlam Mohamed YusufDepartment of Cardiology, First Affiliated Hospital of Ningbo University, Ningbo 315010, China.
Xiehui ChenDepartment of Geriatrics, Shenzhen Longhua District Central Hospital, Shenzhen 518110, China.
Minmin WengNingbo Key Laboratory for Precision Detection of Lipoprotein Subfractions by VAP, Ningbo Meikang Shengde Medical Laboratory, Ningbo 315105, China.
Zhenzhen SuDepartment of Clinical Laboratory, The Fourth Affiliated Hospital of Nanchang University, Nanchang 330002, China.
Wei HuNingbo Key Laboratory for Precision Detection of Lipoprotein Subfractions by VAP, Ningbo Meikang Shengde Medical Laboratory, Ningbo 315105, China.
Nan WuDepartment of Cardiology, First Affiliated Hospital of Ningbo University, Ningbo 315010, China.
Jing XuCollege of Biological & Environmental Sciences, Zhejiang Wanli University, Ningbo 315105, China.ORCID https://orcid.org/0009-0003-4045-4306
Binsheng ChenDepartment of Ultrasound Medicine, Ningbo Yinzhou Hospital of Traditional Chinese Medicine, Ningbo 315105, China.
Lishan WuNingbo Key Laboratory for Precision Detection of Lipoprotein Subfractions by VAP, Ningbo Meikang Shengde Medical Laboratory, Ningbo 315105, China.
Wei SunNingbo Key Laboratory for Precision Detection of Lipoprotein Subfractions by VAP, Ningbo Meikang Shengde Medical Laboratory, Ningbo 315105, China.
Xiaomin ChenDepartment of Cardiology, First Affiliated Hospital of Ningbo University, Ningbo 315010, China.
Zhanke WangNingbo Key Laboratory for Precision Detection of Lipoprotein Subfractions by VAP, Ningbo Meikang Shengde Medical Laboratory, Ningbo 315105, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to investigate the protective effects of sodium pyruvate against diabetic atherosclerosis in rats by reducing oxidative stress, ox-LDL levels, and inflammatory responses. Wistar rats were randomly divided into four groups: normal control (NC), diabetes mellitus (DM), diabetic atherosclerosis (DA), and diabetic atherosclerosis treated with sodium pyruvate (DA + SP). Serum levels of malondialdehyde (MDA), superoxide dismutase (SOD), remnant-like particle cholesterol (RLP-C), ox-LDL, low-density lipoprotein particle (LDL-P), the ox-LDL/LDL-P ratio, high-sensitivity C-reactive protein (hs-CRP), and interleukin-6 (IL-6) were measured. Compared with NC and DM groups, DA rats exhibited increased oxidative stress, lipoprotein abnormalities, and inflammation, evidenced by elevated MDA, RLP-C, ox-LDL, LDL-P, ox-LDL/LDL-P ratio, hs-CRP, and IL-6, along with reduced SOD levels. Sodium pyruvate treatment significantly decreased MDA, ox-LDL, ox-LDL/LDL-P ratio, hs-CRP, and IL-6, while increasing SOD activity compared with the DA group. No significant differences in RLP-C and LDL-P were observed between DA and DA + SP groups. Sodium pyruvate alleviates oxidative stress and inflammation and reduces ox-LDL-related indices, suggesting a protective role in diabetic atherosclerosis.

Indexed as

diabetic atherosclerosisinflammationoxidative stressox-LDLox-LDL/LDL-Psodium pyruvate

Identifiers

PMID42221748
PMCPMC13218308

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.