Evidence map›Paper›PMID 42221945›Full record

ArticleFrontiers in veterinary science2026

Microscopic and computational analysis of the stomach, duodenum, and liver of rats with induced hyperprolactinemia treated with exogenous melatonin.

João Vitor da Silva, Ryan Cristian da Silva, Renan Gabriel da Silva Ferreira, Alison José da Silva, Isaque Bertoldo Santos da Silva, Aline Maria Rodrigues Dos Santos, Bruno José do Nascimento, Elba Verônica Matoso Maciel de Carvalho, Francisco Carlos Amanajás de Aguiar Júnior, Ewerton Fylipe de Araújo Silva and 5 more

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Article in Frontiers in veterinary science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

João Vitor da SilvaDepartment of Histology and Embryology, Federal University of Pernambuco, Recife, Pernambuco, Brazil.
Ryan Cristian da SilvaDepartment of Histology and Embryology, Federal University of Pernambuco, Recife, Pernambuco, Brazil.
Renan Gabriel da Silva FerreiraDepartment of Histology and Embryology, Federal University of Pernambuco, Recife, Pernambuco, Brazil.
Alison José da SilvaDepartment of Histology and Embryology, Federal University of Pernambuco, Recife, Pernambuco, Brazil.
Isaque Bertoldo Santos da SilvaDepartment of Histology and Embryology, Federal University of Pernambuco, Recife, Pernambuco, Brazil.
Aline Maria Rodrigues Dos SantosDepartment of Histology and Embryology, Federal University of Pernambuco, Recife, Pernambuco, Brazil.
Bruno José do NascimentoDepartment of Animal Morphology and Physiology, Federal University Rural of Pernambuco, Recife, Pernambuco, Brazil.
Elba Verônica Matoso Maciel de CarvalhoDepartment of Biochemistry, Federal University of Pernambuco, Recife, Pernambuco, Brazil.
Francisco Carlos Amanajás de Aguiar JúniorDepartment of Histology, Federal University of Pernambuco, Vitória de Santo Antão, Pernambuco, Brazil.
Ewerton Fylipe de Araújo SilvaDepartment of Anatomy, Federal University of Pernambuco, Vitória de Santo Antão, Pernambuco, Brazil.
Priscilla Virgínio de AlbuquerqueDepartment of Animal Morphology and Physiology, Federal University Rural of Pernambuco, Recife, Pernambuco, Brazil.
Apolônio Gomes RibeiroAnimal Science Department, Universidade Federal da Paraíba, Areia, Paraíba, Brazil.
Bruno Mendes TenorioDepartment of Histology and Embryology, Federal University of Pernambuco, Recife, Pernambuco, Brazil.
Lucas Rannier Ribeiro Antonino CarvalhoDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Fernanda das Chagas Angelo Mendes TenorioDepartment of Histology and Embryology, Federal University of Pernambuco, Recife, Pernambuco, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: This study evaluated the effects of exogenous melatonin (MEL) on morphological and computational alterations in the stomach, duodenum, and liver of hyperprolactinemic rats. Methods: Twenty-four animals were divided into three groups: Control ( Results: The Hyper group showed a higher body weight compared to the Control group, while both hyperprolactinemic groups exhibited gastric lumen dilation. PCNA immunolabeling increased in the liver and, to a lesser extent, in the stomach, while decreasing in the duodenum in the Hyper and Hyper+MEL groups. In the duodenum, both hyperprolactinemic groups exhibited increased villus and microvillus height, whereas a reduced Periodic Acid-Schiff (PAS)-stained area was detected only in the Hyper group. In the liver, microsteatosis, fewer Kupffer cells (KCs), and a higher number of binucleated hepatocytes were identified in hyperprolactinemic animals. Fractal analysis of goblet cells revealed no differences among groups. Serum MEL levels were elevated in the hyperprolactinemic groups, with the highest concentrations observed in the Hyper+MEL group. Discussion: In summary, hyperprolactinemia induced structural alterations in the stomach, duodenum, and liver, whereas MEL administration exerted limited effects, mainly influencing body weight and duodenal histochemical parameters, without consistent protective effects on the other evaluated outcomes.

Indexed as

digestive systemfractalhistopathologyhyperprolactinemiamelatonin

Identifiers

PMID42221945
PMCPMC13215833

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.