Evidence map›Paper›PMID 42221979›Full record

ReviewNeuro-oncology advances2026

The molecular profile of gliomas in adolescents and young adults.

Anthony C Wang, Winson S Ho, Lissa C Baird

Abstract readReview
In one paragraph

Review in Neuro-oncology advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Anthony C WangDepartment of Neurosurgery, University of California, Los Angeles, California, USA.
Winson S HoDepartment of Neurosurgery, University of California, San Francisco, California, USA (W.H.).
Lissa C BairdDepartment of Neurosurgery, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA (L.C.B.).ORCID https://orcid.org/0000-0001-7996-1020

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adolescents and young adults (AYAs), defined as individuals aged 15-39, represent a distinct and underrepresented population in glioma research and clinical care. Gliomas are the most common central nervous system (CNS) tumors in this population and span both pediatric and adult molecular subtypes, making diagnosis and treatment particularly complex. While the 2021 WHO classification of CNS tumors underscores key molecular differences across age groups, there remain limited standardized, age-specific guidelines for AYA patients. Molecular profiling is especially critical in this demographic, as more than 80% of AYA gliomas harbor potentially targetable alterations, including IDH mutations and

Indexed as

AYA (adolescents and young adults)BRAFgliomasH3K27MIDHmolecularWHO CNS5

Identifiers

PMID42221979
PMCPMC13221130

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.