Evidence map›Paper›PMID 42222005›Full record

ArticleFood chemistry: X2026

Preparation of sea cucumber collagen hydrolysate and its inhibitory effect on α-glucosidases.

Zhe Xu, Xu Yan, Zijin Qin, Rui Zhang, Xiufang Dong, Tengfei Li, Zihao Zhang, Jiale Chang, Tingting Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Food chemistry: X, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhe XuCollege of Life Sciences, Key Laboratory of Biotechnology and Bioresources Utilization, Dalian Minzu University, Ministry of Education, Dalian, Liaoning 116600, China.
Xu YanCollege of Life Sciences, Key Laboratory of Biotechnology and Bioresources Utilization, Dalian Minzu University, Ministry of Education, Dalian, Liaoning 116600, China.
Zijin QinDepartment of Food Science and Technology, University of Georgia, Athens, GA 30602, USA.
Rui ZhangSchool of Food Science and Technology, National Engineering Research Center of Seafood, Collaborative Innovation Center of Seafood Deep Processing, Dalian Polytechnic University, Dalian 116034, China.
Xiufang DongSchool of Public Health, Dali University, Dali 671000, China.
Tengfei LiCollege of Life Sciences, Key Laboratory of Biotechnology and Bioresources Utilization, Dalian Minzu University, Ministry of Education, Dalian, Liaoning 116600, China.
Zihao ZhangCollege of Life Sciences, Key Laboratory of Biotechnology and Bioresources Utilization, Dalian Minzu University, Ministry of Education, Dalian, Liaoning 116600, China.
Jiale ChangCollege of Life Sciences, Key Laboratory of Biotechnology and Bioresources Utilization, Dalian Minzu University, Ministry of Education, Dalian, Liaoning 116600, China.
Tingting LiCollege of Life Sciences, Key Laboratory of Biotechnology and Bioresources Utilization, Dalian Minzu University, Ministry of Education, Dalian, Liaoning 116600, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-alcoholic fatty liver disease (NAFLD) is a chronic metabolic disorder characterized by excessive hepatic lipid accumulation. Emerging evidence suggests that digestive enzymes such as α-glucosidase regulate lipid and glucose homeostasis through postprandial metabolic pathways and may represent a potential therapeutic target for NAFLD management. This study investigated the α-glucosidase inhibitory activity of sea cucumber collagen peptides. Five collagen hydrolysates were prepared, among which the hydrolysate obtained by pepsin digestion for 2 h followed by trypsin digestion for 3 h (SDP 2 h + T 3 h) exhibited the strongest inhibitory activity. A peptide, RDDPEPSYK (RDD), was isolated and identified as a specific α-glucosidase inhibitor. RDD showed inhibitory efficacy comparable to acarbose and significantly reduced lipid accumulation by downregulating lipid synthesis-related proteins, including SREBP-1C and FAS. These findings suggest that sea cucumber collagen peptides may have potential applications in anti-obesity and anti-hepatic steatosis interventions.

Indexed as

Enzymatic hydrolysisEnzyme inhibitionLipid accumulationMolecular interactionPeptide selection

Identifiers

PMID42222005
PMCPMC13216732

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.