ArticleFrontiers in pediatrics2025
A serum exosomal four-miRNA signature for the diagnosis of central precocious puberty: a discovery and validation study.
Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Pulmonary Artery Growth Among Duct-Dependent Physiology After Ductal Stenting Compared to Modified Blalock-Taussig Shunt: Insights from a Systematic Review and Meta-Analysis.Pediatric cardiology · 2026Review
- Global, regional, and national burden of Clostridioides difficile infection (1990-2021) with projections to 2051: A multimodal analysis integrating machine learning (SHAP-XGBoost) and GBD 2021 data.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
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Authors and funding
6 authors.
Funding
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Abstract
Background: The current diagnosis of central precocious puberty (CPP) relies on the invasive and time-consuming GnRH stimulation test. There is an urgent need for convenient, molecular-level non-invasive biomarkers. This study aimed to characterize serum exosomal miRNA profiles and construct a robust diagnostic model to distinguish treatment-naïve CPP patients from healthy controls. Methods: A prospective study enrolled 120 girls (Healthy Controls, Results: Sequencing identified 92 differentially expressed small RNAs, predominantly miRNAs. Bioinformatics analysis revealed significant enrichment of the GnRH signaling pathway (FDR = 2.8 × 10 Conclusion: This study establishes a novel serum exosomal four-miRNA signature as a highly sensitive and specific non-invasive diagnostic tool for CPP. Beyond diagnostic performance, the signature offers molecular insights connecting circulating markers to the GnRH and metabolic pathways. This model presents a promising alternative to invasive testing and lays a foundation for precision diagnostics in pediatric endocrinology.
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