ArticleFrontiers in endocrinology2026
Impact of GnRH antagonist protocols versus progestin-primed ovarian stimulation on reproductive outcomes in advanced reproductive age women: a propensity score-matched retrospective cohort study.
Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: This study aims to compare the live birth rate (LBR) and reproductive outcomes between gonadotropin-releasing hormone antagonist (GnRH-ant) and progestin-primed ovarian stimulation (PPOS) protocols in infertile women of advanced reproductive age (ARA). Methods: A retrospective analysis was conducted on 1588 female patients with ARA who underwent Results: Non-significant differences were observed in baseline characteristics between the two groups. Regarding cycle data, the total gonadotropin dosage was significantly lower in the GnRH-ant group ( Conclusion: This study indicates that the GnRH-ant stimulation protocol is advantageous as compared to the PPOS protocol for infertile women with ARA undergoing controlled ovarian stimulation combined with frozen embryo transfer, as evidenced by improved embryological outcomes, higher CPRs, and higher LBRs.
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