Evidence map›Paper›PMID 42222072›Full record

ArticleFrontiers in endocrinology2026

Impact of GnRH antagonist protocols versus progestin-primed ovarian stimulation on reproductive outcomes in advanced reproductive age women: a propensity score-matched retrospective cohort study.

Zhaokang Qi, Tingting Wang, Jinxin Ren, Shuai Zhao, Jingyan Song, Fang Lian, Yuewen Zhao

Abstract readComparative Study
In one paragraph

Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhaokang QiThe First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, China.
Tingting WangThe First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, China.
Jinxin RenThe First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, China.
Shuai ZhaoThe First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, China.
Jingyan SongThe First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, China.
Fang LianDepartment of Reproduction and Genetics, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
Yuewen ZhaoCReATe Fertility Centre, Toronto, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: This study aims to compare the live birth rate (LBR) and reproductive outcomes between gonadotropin-releasing hormone antagonist (GnRH-ant) and progestin-primed ovarian stimulation (PPOS) protocols in infertile women of advanced reproductive age (ARA). Methods: A retrospective analysis was conducted on 1588 female patients with ARA who underwent Results: Non-significant differences were observed in baseline characteristics between the two groups. Regarding cycle data, the total gonadotropin dosage was significantly lower in the GnRH-ant group ( Conclusion: This study indicates that the GnRH-ant stimulation protocol is advantageous as compared to the PPOS protocol for infertile women with ARA undergoing controlled ovarian stimulation combined with frozen embryo transfer, as evidenced by improved embryological outcomes, higher CPRs, and higher LBRs.

Indexed as

Gonadotropin-Releasing HormoneHormone AntagonistsInfertility, FemaleOvulation InductionProgestinsAdultAdvanced Maternal AgeBirth RateFemaleFertilization in VitroHumansLive BirthPregnancyPregnancy OutcomePregnancy RatePropensity ScoreGonadotropin-Releasing HormoneHormone AntagonistsProgestinsARA womenGnRH antagonist protocolinfertilitylive birth ratePPOS protocol

Identifiers

PMID42222072
PMCPMC13215835

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.