ReviewFrontiers in endocrinology2026
PFAS exposure and reproductive dysfunction: implications for outcomes in assisted reproductive technologies.
Review in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
8 authors.
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Abstract
The high stability and bioaccumulation potential of per- and polyfluoroalkyl substances (PFAS) have led to their widespread environmental presence and raised concerns about human health exposure through multiple pathways. In particular, PFAS exposure during assisted reproductive technology (ART) has attracted increasing attention from the scientific community. Current evidence indicates that PFAS may be associated with diminished fertility, adverse pregnancy outcomes, and impaired fetal health, although the underlying mechanisms remain incompletely elucidated. Emerging studies suggest that these effects may arise from multi-level disruptions of the reproductive system, including interference with hypothalamic-pituitary-gonadal axis regulation, steroidogenesis, gamete quality, oxidative stress and inflammatory signaling, as well as compromised endometrial receptivity and placental function. This review synthesizes and analyzes existing research to explore the impact of PFAS on reproductive outcomes following ART. It highlights potential risks to reproductive health and offers updated perspectives for researchers and public health policymakers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.