ArticleFrontiers in cardiovascular medicine2026
A comparison of sequential density ultracentrifugation and density gradient ultracentrifugation for the proteomic analysis of high-density lipoprotein.
Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: With the failure of high-density lipoprotein (HDL) cholesterol raising therapies to reduce cardiovascular risk, attention has turned towards HDL composition and function. There are several techniques for the isolation of lipoproteins from plasma, with density ultracentrifugation considered the gold-standard method. It is not known which form of density ultracentrifugation is optimal for HDL composition and function analyses. Methods: This study compared HDL composition by nLC-MS/MS and ELISA, subclass distribution by gel electrophoresis, and Results: HDL composition differed between the two isolation techniques, with DGU-isolated HDL fractions containing a higher total protein content than SDU (10.14 ± 1.49 mg/mL compared to 3.18 ± 1.10 mg/mL respectively, Conclusion: Further steps may need to be added to DGU methods to obtain a 'cleaner' HDL fraction and therefore currently SDU is better suited to studies of HDL composition and function.
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