SynthesisFrontiers in pharmacology2026
Therapeutic effects of traditional Chinese medicine injections with heat-clearing and detoxifying properties on viral pneumonia: a systematic review and network meta-analysis.
Synthesis in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The history of traditional Chinese medicine is extensive and well-documented. Various traditional Chinese medicine injections (TCMIs) with heat-clearing and detoxifying properties, developed from classical ancient prescriptions, have been widely used in the treatment of viral pneumonia. To evaluate the efficacy and safety of various heat-clearing and detoxifying TCMIs for the treatment of viral pneumonia through a network meta-analysis. Methods: We searched eight databases to identify randomized controlled trials (RCTs) that examined heat-clearing and detoxifying TCMIs combined with conventional medicine (CM) for the treatment of viral pneumonia, published until 12 December 2025. We used R software for the Bayesian network meta-analysis. Results: Our study included 83 RCTs with a total sample size of 8,678 participants, representing seven different types of heat-clearing and detoxifying TCMIs: Reduning Injection (RDN), Xiyanping Injection (XYP), Yanhuning Injection (YHN), Tanreqing Injection (TRQ), Xuebijing Injection (XBJ), Shuanghuanglian Injection (SHL), and Qingkailing Injection (QKL). RDN + CM was the most effective treatment for shortening cough disappearance and hospitalization time, reducing interleukin-6 level, and increasing the cluster of differentiation 4/cluster of differentiation 8 ratio. Additionally, RDN + CM also showed a significant reduction in adverse events compared to CM. QKL + CM demonstrated the best results in improving the total clinical efficacy rate, shortening antipyretic time, and decreasing the duration of lung rales. Meanwhile, YHN + CM proved most effective at alleviating asthma, while also reducing levels of tumor necrosis factor alpha and high-sensitivity C-reactive protein. Conclusion: Patients with viral pneumonia benefit significantly from the use of heat-clearing and detoxifying TCMIs along with CM. Based on patient outcomes, RDN shows considerable promise and may be the preferred choice of TCMIs for the treatment of viral pneumonia. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42024610013.
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