Evidence map›Paper›PMID 42222808›Full record

ArticleACS omega2026

Evaluating 7‑Aminopyrazolo[4,3‑

Kyriakos Georgiou, Maria Lamprakopoulou, Hannes Buthmann, Sabrina Böing, Athanasios Pousias, Aaron Dexter, Elizabeth Xin Yin Chew, Xianglin Huang, Eleni Ioanna Michalettou, Abigail Pearce and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Kyriakos GeorgiouLaboratory of Medicinal Chemistry, Section of Pharmaceutical Chemistry, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis-Zografou, 15771 Athens, Greece.ORCID https://orcid.org/0009-0003-5454-904X
Maria LamprakopoulouLaboratory of Medicinal Chemistry, Section of Pharmaceutical Chemistry, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis-Zografou, 15771 Athens, Greece.
Hannes ButhmannDepartment of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, U.K.ORCID https://orcid.org/0009-0007-8231-1791
Sabrina BöingDepartment of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, U.K.
Athanasios PousiasLaboratory of Medicinal Chemistry, Section of Pharmaceutical Chemistry, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis-Zografou, 15771 Athens, Greece.
Aaron DexterDepartment of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, U.K.ORCID https://orcid.org/0009-0000-4015-8273
Elizabeth Xin Yin ChewDepartment of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, U.K.
Xianglin HuangDepartment of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, U.K.
Eleni Ioanna MichalettouLaboratory of Medicinal Chemistry, Section of Pharmaceutical Chemistry, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis-Zografou, 15771 Athens, Greece.
Abigail PearceDepartment of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, U.K.ORCID https://orcid.org/0000-0001-9845-0541
Yannis DotsikasLaboratory of Pharmaceutical Analysis, Section of Pharmaceutical Chemistry, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis-Zografou, 15771 Athens, Greece.ORCID https://orcid.org/0000-0003-0882-8286
Nicole PouliLaboratory of Medicinal Chemistry, Section of Pharmaceutical Chemistry, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis-Zografou, 15771 Athens, Greece.
Panagiotis MarakosLaboratory of Medicinal Chemistry, Section of Pharmaceutical Chemistry, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis-Zografou, 15771 Athens, Greece.
Antonios KolocourisLaboratory of Medicinal Chemistry, Section of Pharmaceutical Chemistry, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis-Zografou, 15771 Athens, Greece.ORCID https://orcid.org/0000-0001-6110-1903
Graham LaddsDepartment of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, U.K.ORCID https://orcid.org/0000-0001-7320-9612
Nikolaos LougiakisLaboratory of Medicinal Chemistry, Section of Pharmaceutical Chemistry, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis-Zografou, 15771 Athens, Greece.ORCID https://orcid.org/0000-0003-0582-4415

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to improve the adenosine receptor (AR) subtype selectivity of the previously reported 7-benzylamino-1-methyl-3-phenyl-pyrazolo-[3,4-

Identifiers

PMID42222808
PMCPMC13216935

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.