SynthesisAlzheimer's & dementia : the journal of the Alzheimer's Association2026
Factors linked to informal caregiver burden in dementia across Latin America and the Caribbean: A systematic review and meta-analysis.
Paula Quintero-Cardona, María Alejandra Tangarife, John Blandon, Juan Carlos Arango-Lasprilla, Agustin Ibanez, Sandra Baez
Abstract readSystematic ReviewMeta-Analysis
In one paragraphSynthesis in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
6 authors.
Paula Quintero-CardonaUniversidad de los Andes, Bogotá, Colombia.
María Alejandra TangarifeUniversidad de los Andes, Bogotá, Colombia.
John BlandonUniversidad de los Andes, Bogotá, Colombia.
Juan Carlos Arango-LasprillaDepartment of Cell Biology and Histology, University of the Basque Country UPV/EHU, Leioa, Spain.
Agustin IbanezBarcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.
Funding
An automated machine learning approach to language changes in Alzheimer’s disease and frontotemporal dementia across Latino and English-speaking populationsR01AG075775 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARIA LUISA GORNO TEMPINI, Adolfo Martin Garcia · 2023 to 2026
$7.2MUS-South American Initiative for Genetic-Neural-Behavioral Interactions in Human Neurodegenerative ResearchR01AG057234 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Claudia Duran-Aniotz, Agustin M. Ibanez · 2019 to 2026
$6.1MCircadian Disturbance and Dementia in Latin AmericaR01AG083799 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Kun Hu, Agustin M. Ibanez · 2023 to 2026
$3.0MAlzheimer's Association SG-20-725707Alzheimer's Society UK GBHIALZUK-25-1289623ANID/FONDAP 15150012ANID/FONDECYT 1210176ANID/FONDECYT 1220995ANID/FONDECYT 1250091ANID/PIA/ANILLOS ACT210096DISCeRN 2025 - Health and Social Care Research with a Focus on the Moderate and Late Stages of Neurodegenerative DiseasesFogarty International Center (FIC), National Institutes of Health, National Institutes of Aging CARDS-NIHFogarty International Center (FIC), National Institutes of Health, National Institutes of Aging R01AG057234Fogarty International Center (FIC), National Institutes of Health, National Institutes of Aging R01AG075775Fogarty International Center (FIC), National Institutes of Health, National Institutes of Aging R01AG083799Fogarty International Center (FIC), National Institutes of Health, National Institutes of Aging R01AG21051FONDEF 20I10152Global Brain Health InstituteMarie Skłodowska-Curie Actions - MSCA 101236426Multi-Partner Consortium to Expand Dementia Research in Latin America (ReDLat)NIA NIH HHS R01 AG057234NIA NIH HHS R01 AG075775NIA NIH HHS R01 AG083799NIDA NIH HHS 75N95022C00031Pilot Awards for Global Brain Health Leaders GBHI ALZ UK-25-1289623Rainwater Charitable Foundation - The Bluefield project to cure FTD, and Global Brain Health InstituteWellcome Leap CARE Program CARE-2025-0883490149Wellcome TrustWellcome Trust 335293/Z/25/Z
6 · The paper itselfAbstract
Informal caregivers are central to dementia care in Latin America and the Caribbean (LAC), yet determinants of caregiver burden remain insufficiently characterized. We conducted a systematic review and meta-analysis of studies examining patient- and caregiver-related correlates of burden in LAC. Random-effects models pooled Fisher's z-transformed correlations. Forty studies were included, of which 34 (n = 3,082 caregivers) were meta-analyzed. Higher burden was associated with the patient's neuropsychiatric and depressive symptoms, and caregiver depressive and anxiety symptoms. Better patient cognition and quality of life were associated with lower burden. Meta-regressions showed that higher caregiver education strengthened the association between patient depressive symptoms and burden, and a higher proportion of female caregivers strengthened the association between patient cognition and burden. Findings highlight the role of behavioral and affective symptoms and support culturally grounded, gender-sensitive strategies in LAC. High heterogeneity underscores the need for methodological harmonization and further regional research.
Indexed as
CaregiversCost of IllnessDementiaCaribbean RegionDepressionHumansLatin AmericaQuality of Lifecaregiver burdencognitionDementiadepressioneducationfunctional dependencegenderinformal careLatin Americameta‐analysisneuropsychiatric symptomsquality of lifesystematic review
Identifiers
PMID42222927
PMCPMC13239666
What Socratic holds
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