Evidence map›Paper›PMID 42222994›Full record

Trial reportMovement disorders : official journal of the Movement Disorder Society2026

Transcranial Pulse Stimulation Enhances Dexterity in Parkinson's Disease: A Randomized Sham-Controlled Trial.

Eva Matt, Nina Plischek, Michael Mitterwallner, Sonja Radjenovic, Alexandra Weber, Alina Domitner, Gregor Dörl, Anna Zettl, Sarah Osou, Anna Leitgeb and 5 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Movement disorders : official journal of the Movement Disorder Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Extracorporeal shockwave therapy in tissue repair and regeneration.Wiener medizinische Wochenschrift (1946) · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Eva MattFunctional Brain Diagnostics and Therapy, Department of Neurology, Medical University of Vienna, Vienna, Austria.ORCID https://orcid.org/0000-0003-2343-2191
Nina PlischekFunctional Brain Diagnostics and Therapy, Department of Neurology, Medical University of Vienna, Vienna, Austria.
Michael MitterwallnerFunctional Brain Diagnostics and Therapy, Department of Neurology, Medical University of Vienna, Vienna, Austria.ORCID https://orcid.org/0009-0004-6643-6445
Sonja RadjenovicFunctional Brain Diagnostics and Therapy, Department of Neurology, Medical University of Vienna, Vienna, Austria.
Alexandra WeberFunctional Brain Diagnostics and Therapy, Department of Neurology, Medical University of Vienna, Vienna, Austria.
Alina DomitnerFunctional Brain Diagnostics and Therapy, Department of Neurology, Medical University of Vienna, Vienna, Austria.
Gregor DörlFunctional Brain Diagnostics and Therapy, Department of Neurology, Medical University of Vienna, Vienna, Austria.
Anna ZettlFunctional Brain Diagnostics and Therapy, Department of Neurology, Medical University of Vienna, Vienna, Austria.
Sarah OsouFunctional Brain Diagnostics and Therapy, Department of Neurology, Medical University of Vienna, Vienna, Austria.
Anna LeitgebFunctional Brain Diagnostics and Therapy, Department of Neurology, Medical University of Vienna, Vienna, Austria.
Agnes SanterDepartment of Neurology, Medical University of Vienna, Vienna, Austria.
Viktoria WinklerDepartment of Neurology, Medical University of Vienna, Vienna, Austria.
Julia MandelburgerDepartment of Neurology, Medical University of Vienna, Vienna, Austria.
Heidemarie ZachDepartment of Neurology, Medical University of Vienna, Vienna, Austria.
Roland BeisteinerFunctional Brain Diagnostics and Therapy, Department of Neurology, Medical University of Vienna, Vienna, Austria.ORCID https://orcid.org/0000-0002-6410-5990

Funding

Herzfelder'sche FamilienstiftungMedizinische Universität Wien SO10300020Storz Medical AG
6 · The paper itself

Abstract

backgroundUltrasound-based neuromodulation, capable of reaching deep brain areas with high precision, represents cutting-edge technology in non-invasive brain stimulation and is investigated as a novel treatment for neurological and psychiatric disorders, including Parkinson's disease (PD).

objectivesTo evaluate the effects of repeated transcranial pulse stimulation (TPS) applications on motor symptoms, brain structure, and functional activation in PD.

methodsIn this randomized, sham-controlled, double-blind, crossover clinical trial, 30 participants with mild PD underwent six sessions of both verum and sham TPS targeting the sensorimotor network. Comprehensive clinical and magnetic resonance imaging (MRI) assessments were administered at baseline, 1 day, and 1 month post-stimulation for both conditions.

resultsManual dexterity, measured via the coin rotation task, showed significantly larger improvement following verum compared with sham TPS (post-stimulation vs. baseline: P

conclusionsThese findings indicate that TPS produces behavioral, neurophysiological, and structural effects within the targeted sensorimotor network, and may represent a safe and effective adjunct to standard therapies in PD. © 2026 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Indexed as

Parkinson DiseaseTranscranial Direct Current StimulationAgedCross-Over StudiesDouble-Blind MethodFemaleHumansMagnetic Resonance ImagingMaleMiddle Ageddexteritydiffusion tensor imagingfunctional MRIParkinson's diseasetranscranial pulse stimulationultrasound neuromodulation

Identifiers

PMID42222994
PMCPMC13602279

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.