Evidence map›Paper›PMID 42223017›Full record

ArticleeLife2026

Interplay between cohesin and TORC1 links chromosome segregation and gene expression to environmental changes.

Dorian Besson, Sabine Vaur, Stéphanie Vazquez, Sylvie Tournier, Yannick Gachet, Adrien Birot, Stéphane Claverol, Adèle L Marston, Anastasios Damdimopoulos, Karl Ekwall and 1 more

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Dorian Besson *CNRS, Université de Bordeaux - Institut de Biochimie et Génétique Cellulaires, Bordeaux, France.
Sabine Vaur *CNRS, Université de Bordeaux - Institut de Biochimie et Génétique Cellulaires, Bordeaux, France.
Stéphanie VazquezCNRS, Université de Bordeaux - Institut de Biochimie et Génétique Cellulaires, Bordeaux, France.
Sylvie TournierMCD, Centre de Biologie Intégrative, Université de Toulouse, CNRS, UPS, Toulouse Cedex, France.ORCID https://orcid.org/0000-0002-7869-6891
Yannick GachetMCD, Centre de Biologie Intégrative, Université de Toulouse, CNRS, UPS, Toulouse Cedex, France.
Adrien BirotCNRS, Université de Bordeaux - Institut de Biochimie et Génétique Cellulaires, Bordeaux, France.ORCID https://orcid.org/0000-0002-8299-8518
Stéphane ClaverolUniversity of Bordeaux, Bordeaux Proteome, Bordeaux, France.
Adèle L MarstonCentre for Cell Biology, Institute of Cell Biology, University of Edinburgh, Edinburgh, United Kingdom.ORCID https://orcid.org/0000-0002-3596-9407
Anastasios DamdimopoulosDepartment of Medicine, Karolinska Institutet, Stockholm, Sweden.
Karl EkwallDepartment of Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID https://orcid.org/0000-0002-3029-4041
Jean-Paul JaverzatCNRS, Université de Bordeaux - Institut de Biochimie et Génétique Cellulaires, Bordeaux, France.ORCID https://orcid.org/0000-0002-9671-6753

Funding

Fondation ARC pour la Recherche sur le Cancer ARCPJA2021060003810International PhD Programme IdEx University of BordeauxWellcome Discovery Research Platform for Hidden Cell Biology 10.35802/226791Wellcome Investigator Award 10.35802/220780
6 · The paper itself

Abstract

Cohesin is a DNA tethering complex essential for chromosome structure and function. In fission yeast, defects in the cohesin loader Mis4 result in chromosome segregation defects and dysregulated expression of genes near chromosome ends. A genetic screen for suppressors of the thermosensitive growth defect of

Indexed as

Cell Cycle ProteinsChromosomal Proteins, Non-HistoneChromosome SegregationGene Expression Regulation, FungalMechanistic Target of Rapamycin Complex 1SchizosaccharomycesSchizosaccharomyces pombe ProteinsCohesinsPhosphorylationCell Cycle ProteinsChromosomal Proteins, Non-HistoneCohesinsMechanistic Target of Rapamycin Complex 1Schizosaccharomyces pombe Proteinsadaptive responsechromosomeschromosome segregationcohesingene expressionphosphorylationS. pombeTORC1

Identifiers

PMID42223017
PMCPMC13225845

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.