Evidence map›Paper›PMID 42223325›Full record

ArticleClinical cardiology2026

Evaluation of Polygenic Scores and CT Imaging in Risk Factor Modification in Patients With Diabetes: Rationale and Design of the VOLTAIRE Study.

Ruofei Chen, Adam J Nelson, Sophia Zoungas, Robyn A Clark, Sean Tan, Esther F Davis, Melissa C Southey, Domenic Sacca, Andrew Lin, Giuseppe Di Giovanni and 3 more

Abstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ruofei ChenMonash Victorian Heart Institute, Monash University, Melbourne, Victoria, Australia.
Adam J NelsonMonash Victorian Heart Institute, Monash University, Melbourne, Victoria, Australia.
Sophia ZoungasSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Robyn A ClarkCaring Future Institute, College of Nursing and Health Sciences, Flinders University, Adelaide, South Australia, Australia.
Sean TanMonash Victorian Heart Institute, Monash University, Melbourne, Victoria, Australia.
Esther F DavisMonash Victorian Heart Institute, Monash University, Melbourne, Victoria, Australia.
Melissa C SoutheyMonash Victorian Heart Institute, Monash University, Melbourne, Victoria, Australia.
Domenic SaccaMonash Victorian Heart Institute, Monash University, Melbourne, Victoria, Australia.
Andrew LinMonash Victorian Heart Institute, Monash University, Melbourne, Victoria, Australia.
Giuseppe Di GiovanniMonash Victorian Heart Institute, Monash University, Melbourne, Victoria, Australia.
Masashi FujinoMonash Victorian Heart Institute, Monash University, Melbourne, Victoria, Australia.ORCID https://orcid.org/0000-0002-2706-4317
Tayla MicheliMonash Victorian Heart Institute, Monash University, Melbourne, Victoria, Australia.
Stephen J NichollsMonash Victorian Heart Institute, Monash University, Melbourne, Victoria, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe contemporary management of type 2 diabetes (T2D) involves a multifaceted model of care integrating intensive management of lipids, blood pressure, and glucose, along with lifestyle modifications. Despite these efforts, cardiovascular disease (CVD) remains a leading cause of morbidity and mortality among patients with T2D, largely due to suboptimal adherence to preventive strategies. The VOLTAIRE trial aims to assess the impact of providing personalized cardiovascular risk information derived from computed tomography coronary angiography (CTCA) and a polygenic risk score (PRS) on cardiovascular risk factor modification.

objectivesVOLTAIRE evaluates whether integrating CTCA and PRS into risk counseling enhances adherence to lifestyle and pharmacological interventions, ultimately improving cardiovascular outcomes among patients with T2D.

methodsVOLTAIRE is a prospective three-arm, parallel-group, randomized controlled trial enrolling participants aged 40 years or older with T2D and no established atherosclerotic CVD. Participants are randomized 1:1:1 to receive: (1) risk factor counseling plus CTCA result, (2) risk factor counseling plus PRS result, or (3) standard risk factor counseling (control). Nurse-led motivational interviewing is used for risk counseling. The primary outcome is change in non-calcified plaque volume measured by serial CTCA at 12 months. Secondary outcomes include low-density lipoprotein cholesterol levels, adherence to medication, patient engagement, CVD knowledge improvements, and psychological outcomes over 12 months. Enrollment began in August 2023. DISCUSSION: VOLTAIRE seeks to determine if coupling nurse-led risk factor counseling with personalized CTCA or PRS information improves cardiovascular outcomes, adherence, and participant engagement in T2D management.

Indexed as

Cardiovascular DiseasesComputed Tomography AngiographyCoronary AngiographyDiabetes Mellitus, Type 2Risk Reduction BehaviorAdultFemaleGenetic Risk ScoreHeart Disease Risk FactorsHumansMaleProspective StudiesRandomized Controlled Trials as TopicRisk AssessmentRisk Factorscardiovascular diseasecomputed tomography coronary angiographydiabetespolygenic risk scorerisk factor

Identifiers

PMID42223325
PMCPMC13240284

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.