ArticleJournal of clinical hypertension (Greenwich, Conn.)2026
Associations of Long-Term Blood Pressure Burden and Variability With Kidney Function Decline.
Article in Journal of clinical hypertension (Greenwich, Conn.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Long-term blood pressure (BP) burden and visit-to-visit BP variability may better capture cumulative hemodynamic stress on the kidneys than single-visit BP measurements, yet evidence linking these metrics with kidney function decline in the general population remains limited. We analyzed 2,821 adults with preserved kidney function from a prospective cohort study. Cumulative BP exposure and visit-to-visit BP variability were derived from BP measurements obtained at baseline and two follow-up visits. Outcomes included annual estimated glomerular filtration rate (eGFR) slope and study-defined incident chronic kidney disease (CKD). Higher long-term BP exposure, particularly systolic BP (SBP), and greater BP variability were associated with faster kidney function decline. A 1-standard deviation increase in cumulative SBP was associated with a more negative annual eGFR slope (β≈-0.15 to -0.18 mL/min/1.73 m
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