Evidence map›Paper›PMID 42223647›Full record

ReviewResults and problems in cell differentiation2026

Application of Bioactive Natural Compounds to Promote Cell Proliferation and Migration in the Wound Healing Process.

Kamila Kozłowska-Tomczyk, Zuzanna Flis, Justyna Gogola-Mruk, Piotr Szatkowski, Edyta Molik, Anna Ptak

Abstract readReview
PubMed Publisher
In one paragraph

Review in Results and problems in cell differentiation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kamila Kozłowska-TomczykLaboratory of Physiology and Toxicology of Reproduction, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University, Krakow, Poland.
Zuzanna FlisDepartment of Animal Biotechnology, Faculty of Animal Science, University of Agriculture in Krakow, Krakow, Poland.
Justyna Gogola-MrukLaboratory of Physiology and Toxicology of Reproduction, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University, Krakow, Poland.
Piotr SzatkowskiDepartment of Glass Technology and Amorphous Coatings, Faculty of Materials Science and Ceramics, AGH University of Krakow, Krakow, Poland.
Edyta MolikDepartment of Animal Biotechnology, Faculty of Animal Science, University of Agriculture in Krakow, Krakow, Poland.
Anna PtakLaboratory of Physiology and Toxicology of Reproduction, Institute of Zoology and Biomedical Research, Faculty of Biology, Jagiellonian University, Krakow, Poland. anna.ptak@uj.edu.pl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wound healing is a complex biological process that restores the integrity and strength of the skin. Keratinocytes and fibroblasts play pivotal roles in tissue repair through their interactions and signaling pathways. Keratinocytes proliferate to re-epithelialize the wound, while fibroblasts contribute to the formation of new extracellular matrix. Although cell proliferation is essential for wound healing, excessive proliferation can lead to scar formation. Therefore, strategies that balance proliferation and migration, along with proper mechanotransduction, are crucial for efficient wound repair. Sheep and camel milk contain numerous bioactive substances, such as insulin, lactoferrin, proline, and conjugated linoleic acid, that have demonstrated promising effects on wound healing. While direct evidence on skin cell proliferation and migration is limited, the properties of these bioactive substances suggest beneficial effects in these areas. Therefore, incorporating these milks into hydrogel dressings can promote wound healing. Moreover, improving the cell-material mechano-interaction in such hydrogels could lead to the development of novel regenerative medical therapies.

Indexed as

Biological ProductsCell MovementCell ProliferationWound HealingAnimalsFibroblastsHumansKeratinocytesMilkSheepBiological ProductsCamel milkFibroblastKeratinocytesMigrationProliferationSheep milkWound healing

Identifiers

PMID42223647

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.