Evidence map›Paper›PMID 42223731›Full record

ArticleMetabolic brain disease2026

Early GPR81/MCT1 rise and late lactate-NAD(H) Build-up in an LPS model of PD.

Arseniy K Berdnikov, Natalia A Kolotyeva, Natalia A Rozanova, Svetlana V Novikova, Anastasia K Pavlova, Artyom S Olshanskiy, Alla V Stavrovskaya, Yulia K Komleva, Alla B Salmina

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In one paragraph

Article in Metabolic brain disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Arseniy K Berdnikov *Federal State Budgetary Scientific Institution "Russian Center of Neurology and Neurosciences", Moscow, 125367, Russia. berdnikov.a.k@neurology.ru.ORCID 0009-0007-4195-2533
Natalia A Kolotyeva *Federal State Budgetary Scientific Institution "Russian Center of Neurology and Neurosciences", Moscow, 125367, Russia.ORCID 0000-0002-7853-6222
Natalia A RozanovaFederal State Budgetary Scientific Institution "Russian Center of Neurology and Neurosciences", Moscow, 125367, Russia.ORCID 0000-0001-9619-4679
Svetlana V NovikovaFederal State Budgetary Scientific Institution "Russian Center of Neurology and Neurosciences", Moscow, 125367, Russia.
Anastasia K PavlovaFederal State Budgetary Scientific Institution "Russian Center of Neurology and Neurosciences", Moscow, 125367, Russia.ORCID 0009-0006-7613-2503
Artyom S OlshanskiyFederal State Budgetary Scientific Institution "Russian Center of Neurology and Neurosciences", Moscow, 125367, Russia.
Alla V StavrovskayaFederal State Budgetary Scientific Institution "Russian Center of Neurology and Neurosciences", Moscow, 125367, Russia.ORCID 0000-0002-8689-0934
Yulia K KomlevaFederal State Budgetary Scientific Institution "Russian Center of Neurology and Neurosciences", Moscow, 125367, Russia.ORCID 0000-0001-5742-8356
Alla B SalminaFederal State Budgetary Scientific Institution "Russian Center of Neurology and Neurosciences", Moscow, 125367, Russia.ORCID 0000-0003-4012-6348

Funding

planned laboratory topic «Aberrant metabolic plasticity of neurovascular unit cells in brain pathology» 1023101100004-9-3.1.8;3.1.4.Russian Science Foundation 24-25-00239
6 · The paper itself

Abstract

Parkinson's disease (PD) is characterized by the development of chronic neuroinflammation and energy metabolism impairment in the substantia nigra. Here we investigated the role of the lactate receptor GPR81 (HCAR1) and lactate metabolism in the inflammatory cascade in vivo in the lipopolysaccharide (LPS)-induced experimental model of PD. The data obtained suggest that GPR81/HCAR1 and MCT1 are dynamically regulated during the inflammatory response in the substantia nigra and may represent part of a compensatory interaction between lactate signaling and glial activation.

Indexed as

Lactic AcidMonocarboxylic Acid TransportersReceptors, G-Protein-CoupledSymportersAnimalsLipopolysaccharidesMaleMiceMice, Inbred C57BLMonocarboxylate Transport Protein 1Substantia NigraHcar1 protein, mouseLactic AcidLipopolysaccharidesMonocarboxylate Transport Protein 1Monocarboxylic Acid TransportersReceptors, G-Protein-CoupledSymportersGPR81Lactate metabolismNeuroinflammationParkinson’s diseaseSubstantia nigra

Identifiers

PMID42223731

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.