Evidence map›Paper›PMID 42223799›Full record

ArticleDrug delivery and translational research2026

Enhancing skin moisture and anti-aging by DL-α-tocopherol loading sodium alginate-based hydrogel microneedles.

Khan Manqoosh Awan, Haojie Yu, Li Wang, Muhammad Haroon, Abdul Basit, Jian Hu, Jingyi Feng, Muhammad Owais Malik, Dileep Ahmad, Saqlain Raza and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Drug delivery and translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Khan Manqoosh AwanState Key Laboratory of Chemical Engineering and Low-Carbon Technology, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310058, P.R. China.
Haojie YuState Key Laboratory of Chemical Engineering and Low-Carbon Technology, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310058, P.R. China. hjyu@zju.edu.cn.
Li WangState Key Laboratory of Chemical Engineering and Low-Carbon Technology, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310058, P.R. China. opl_wl@dial.zju.edu.cn.
Muhammad HaroonState Key Laboratory of Chemical Engineering and Low-Carbon Technology, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310058, P.R. China.
Abdul BasitState Key Laboratory of Chemical Engineering and Low-Carbon Technology, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310058, P.R. China.
Jian HuThe First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310003, P.R. China.
Jingyi FengThe First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310003, P.R. China.
Muhammad Owais MalikState Key Laboratory of Chemical Engineering and Low-Carbon Technology, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310058, P.R. China.
Dileep AhmadState Key Laboratory of Chemical Engineering and Low-Carbon Technology, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310058, P.R. China.
Saqlain RazaState Key Laboratory of Chemical Engineering and Low-Carbon Technology, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310058, P.R. China.
Hammal MajeedState Key Laboratory of Chemical Engineering and Low-Carbon Technology, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310058, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Effective skin moisturization is essential for combating age-related skin deterioration and maintaining overall skin health. This study investigates the development and characterization of DL-α-tocopherol-loaded sodium alginate (SA)-based hydrogel microneedles (MNs) using a polyethylene glycol diglycidyl ether (PEGDE) crosslinking strategy for sustained, non-invasive antioxidant delivery and enhanced skin hydration. Three hydrogel formulations, SAP1, SAP2 and SAP3, were prepared with varying PEGDE to SA molar ratios, resulting in distinct swelling behaviors and crosslinking densities. SAP1 exhibited the highest swelling ratio, while SAP3 showed the lowest, which influenced the drug release profiles. SAP1α provided the fastest drug release, while SAP3α demonstrated a slowest release. SAP2α was selected for in vivo evaluation based on their balanced DL-α-tocopherol release along with favorable mechanical strength and swelling properties. SAP2α MNs significantly increased skin moisture from 13% to 37% within 8 days, outperforming the control and blank groups. These results show the potential of SA-based hydrogel MNs for transdermal drug delivery for skin rejuvenation and anti-aging. The moisturizing effectiveness of SAP2α MNs suggests their strong clinical potential in dermatology and cosmetic treatments for combating skin aging and dryness.

Indexed as

Drug deliveryHydrogel microneedlesSkincareSkin moisturizingSodium alginateα-tocopherol

Identifiers

PMID42223799

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.