ReviewInfection2026
Viral subversion of megakaryopoiesis: reshaping the landscapes of immune regulation.
Review in Infection, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis review provides a brief overview of how viruses influence megakaryocyte development, maturation, and immune responses. Understanding this crucial host-virus pathophysiology will help to mitigate adverse effects by enabling the discovery of new targeted therapeutics.
methodsThis review examines the recent literature on virus-megakaryopoiesis interactions in the context of clinical observations, case studies, systematic cellular and molecular mechanistic data, and finally emerging therapeutic interventions to tackle virus-induced thrombocytopenia.
resultsMegakaryocytes are exploited by many viruses for their survival and replication, thereby impairing proliferation, differentiation, maturation, and platelet release. Such disruptions lead to immune-mediated suppression and thrombocytopenia. Viruses also induce cell death pathways at different stages of megakaryopoiesis via both receptor-dependent and independent mechanisms. Thus, viral infection has a multifaceted effect on megakaryopoiesis, with consequences for host immune regulation and disease pathogenesis.
conclusionIn this review, we provide a brief overview of how viruses influence megakaryocyte development, maturation, and immune responses. Understanding this crucial host-virus pathophysiology is fundamental for developing targeted therapeutics to limit virus-induced adverse effects.
Indexed as
Identifiers
42223845What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.