Evidence map›Paper›PMID 42223879›Full record

ArticleProbiotics and antimicrobial proteins2026

Intestinal-Protective Lactiplantibacillus plantarum DPU-MWM14-103 Exhibits Genomic Adaptations and Multifaceted Probiotic Properties.

Zhao Zhang, Yanchen Liu, Baoyuan Zhao, Zhaobin Yan, Xuemei Zhu, Guangqing Mu, Xiaomeng Wu

Abstract read
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In one paragraph

Article in Probiotics and antimicrobial proteins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhao ZhangSchool of Food Science and Technology, Dalian Polytechnic University, Dalian, 116034, China.
Yanchen LiuSchool of Food Science and Technology, Dalian Polytechnic University, Dalian, 116034, China.
Baoyuan ZhaoSchool of Food Science and Technology, Dalian Polytechnic University, Dalian, 116034, China.
Zhaobin YanSchool of Food Science and Technology, Dalian Polytechnic University, Dalian, 116034, China.
Xuemei ZhuSchool of Food Science and Technology, Dalian Polytechnic University, Dalian, 116034, China.
Guangqing MuSchool of Food Science and Technology, Dalian Polytechnic University, Dalian, 116034, China. guangqingmu@163.com.
Xiaomeng WuSchool of Food Science and Technology, Dalian Polytechnic University, Dalian, 116034, China. wuxiaomeng0812@163.com.

Funding

National Key Research and Development Program of China 2022YFD2101503
6 · The paper itself

Abstract

Lactiplantibacillus plantarum stands out among probiotics for its strong environmental adaptability, diverse metabolic activity, proven safety, and broad functional benefits. To obtain safe L. plantarum strains with gut health-promoting properties, this study systematically screened numerous L. plantarum strains from human breast milk based on their acid and bile tolerance, hydrophobicity, autoaggregation, and antioxidant activity. Its cellular effects were assessed in Caco-2 and IEC-6 intestinal epithelial cell models by evaluating adhesion ability, cytotoxicity, cell cycle distribution, tight junction gene expression (e.g., ZO-1, Occludin), and LPS-induced inflammatory responses. Hemolytic activity and antibiotic resistance profiles were also assessed to ensure safety. Among the screened isolates, Lactiplantibacillus plantarum DPU-MWM14-103 (L. plantarum M14-103) demonstrated strong acid and bile resistance, high hydrophobicity, robust autoaggregation, and potent DPPH radical scavenging activity. Genome analysis revealed the absence of antibiotic resistance and virulence genes, along with the presence of genes associated with stress response and adhesion. In vitro assays confirmed its non-toxic nature, lack of hemolytic activity, and ability to enhance tight junction integrity and reduce inflammatory cytokine expression under LPS stimulation. As a result, L. plantarum M14-103 would be a potential probiotic strain for gut health.

Indexed as

Breast milk-derived probioticsCell barrierCellular immunityGut health

Identifiers

PMID42223879

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.