Evidence map›Paper›PMID 42224595›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Coordinated expression and assembly of BiP, p58

Insook Jang, Alec Duffey, Pamela Itkin-Ansari, Peter Arvan, Randal J Kaufman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Insook JangCancer Metabolism and Microenvironment Program, National Cancer Institute-Designated Cancer Center, Center for Metabolic and Liver Diseases, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037.ORCID 0000-0001-7567-3849
Alec DuffeyCancer Metabolism and Microenvironment Program, National Cancer Institute-Designated Cancer Center, Center for Metabolic and Liver Diseases, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037.ORCID 0009-0007-1272-0602
Pamela Itkin-AnsariCancer Metabolism and Microenvironment Program, National Cancer Institute-Designated Cancer Center, Center for Metabolic and Liver Diseases, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037.
Peter ArvanDivision of Metabolism, Endocrinology and Diabetes, University of Michigan Medical Center, Ann Arbor, MI 48105.ORCID 0000-0002-4007-8799
Randal J KaufmanCancer Metabolism and Microenvironment Program, National Cancer Institute-Designated Cancer Center, Center for Metabolic and Liver Diseases, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037.ORCID 0000-0003-4277-316X

Funding

Structural BiologyP30CA030199 · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · 1985 to 2025
$23.0M
Improving Proinsulin Folding to Ameliorate Type II DiabetesR01DK132689 · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · 2025 to 2025
$760k
HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01DK132689HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R24DK110973HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R37DK042394Juvenile Diabetes Research Foundation 3-SRA-2022-1203-S-BNCI NIH HHS P30 CA030199NIDDK NIH HHS R01 DK132689NIDDK NIH HHS R24 DK110973NIDDK NIH HHS R37 DK042394NIH HHS S10 OD036254
6 · The paper itself

Abstract

Proper proinsulin folding in the endoplasmic reticulum (ER) is prerequisite to producing bioactive insulin, and proinsulin misfolding causing β cell ER stress accompanies pancreatic β cell dysfunction in type 2 diabetes (T2D). How (and which) ER chaperones coordinate to prevent proinsulin misfolding is largely unknown other than an unspecified dependence on the hsp70 member, BiP. A genetically engineered mouse enables efficient, specific pulldown of endogenous islet β cell BiP (GRP78, the major HSP70 ER chaperone) in complexes with client proteins. We demonstrate that BiP assembles in various protein complexes (including cochaperones p58

Indexed as

Endoplasmic ReticulumHeat-Shock ProteinsHSP40 Heat-Shock ProteinsInsulin-Secreting CellsProinsulinAnimalsEndoplasmic Reticulum Chaperone BiPHSP70 Heat-Shock ProteinsMiceMolecular ChaperonesProtein FoldingEndoplasmic Reticulum Chaperone BiPHeat-Shock ProteinsHSP40 Heat-Shock ProteinsHSP70 Heat-Shock ProteinsHspa5 protein, mouseMolecular ChaperonesProinsulinchaperonesendoplasmic reticulumproinsulin foldingtype 2 diabetesβ cell function

Identifiers

PMID42224595
PMCPMC13245649

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.