ArticleRedox biology2026
Oxidative modifications of tuberculosis antigen Ag85B alter its T cell antigenicity.
Article in Redox biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
Mycobacterium tuberculosis (Mtb) remains a global health threat, necessitating innovative vaccine strategies that transcend traditional antigen delivery. While oxidative stress is a hallmark of the host-pathogen interface, the deliberate use of reactive oxygen and nitrogen species (RONS) to modulate antigen immunogenicity remains underexplored. We employed cold physical plasma, a potent source of diverse reactive species, to engineer oxidatively modified Ag85B (oxAg85B) variants. Using high-resolution mass spectrometry, we performed comprehensive oxidative protein modification mapping, identifying a landscape of 59 distinct oxPTMs. The functional impact on cellular immunity was evaluated using transgenic mice harboring Ag85B-specific CD4
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