Evidence map›Paper›PMID 42225830›Full record

ReviewNature cell biology2026

Emerging roles of ferroptosis in modulating the immune landscape of glial tumours.

Michael G Argenziano, Taruna V Neelakantan, Colin Sperring, Oluwaseyi Adeuyan, Dominique M O Higgins, Jeffrey N Bruce, Betty Y S Kim, Athanassios Dovas, Peter Canoll, Michael Lim and 2 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature cell biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Michael G Argenziano *Department of Neurosurgery, Columbia University Irving Medical Center, New York, NY, USA.
Taruna V Neelakantan *Department of Biological Sciences, Department of Chemistry and Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA.
Colin SperringDepartment of Neurosurgery, Columbia University Irving Medical Center, New York, NY, USA.
Oluwaseyi AdeuyanDepartment of Neurosurgery, Columbia University Irving Medical Center, New York, NY, USA.
Dominique M O HigginsDepartment of Neurological Surgery, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Jeffrey N BruceDepartment of Neurosurgery, Columbia University Irving Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-6844-0286
Betty Y S KimDepartment of Neurosurgery, University of Texas, MD Anderson Cancer Center, Houston, Texas, USA.ORCID http://orcid.org/0000-0001-6890-8355
Athanassios DovasDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.
Peter CanollDepartment of Neurosurgery, Columbia University Irving Medical Center, New York, NY, USA.
Michael LimDepartment of Neurosurgery, Stanford University, Palo Alto, CA, USA.ORCID http://orcid.org/0000-0003-0523-3076
Brent R StockwellDepartment of Biological Sciences, Department of Chemistry and Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0002-3532-3868
Matei A BanuDepartment of Neurosurgery, Columbia University Irving Medical Center, New York, NY, USA. mbanu@stanford.edu.ORCID http://orcid.org/0000-0003-2330-1810

Funding

U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) K12/NRCDP
6 · The paper itself

Abstract

The brain offers a unique environment for cancer, with limited access to nutrients and highly regulated immune surveillance. Here we explore the role of ferroptosis, a form of metabolically regulated cell death driven by iron-mediated lipid peroxidation, in shaping immune-cell composition and function in glial tumours. We review the complex metabolic crosstalk between cell populations regulating ferroptosis in the glioma milieu. Ferroptosis induces polarization of resident microglia and controls the cytotoxic roles of CD8

Indexed as

Brain NeoplasmsFerroptosisGliomaAnimalsCD8-Positive T-LymphocytesHumansImmunotherapyMicrogliaT-Lymphocytes, RegulatoryTumor EscapeTumor Microenvironment

Identifiers

PMID42225830

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.