Evidence map›Paper›PMID 42225832›Full record

ArticleNature cell biology2026

Diffusing caveolin-1 scaffolds regulate mechanosignalling.

Satish Kailasam Mani, Nicolas Tardif, Olivier Rossier, Ismail M Khater, Xuesi Zhou, Victor Breton, Filipe Nunes Vicente, Adiyodi Veettil Radhakrishnan, Céline Gracia, Pamela Gonzalez Troncoso and 10 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature cell biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Satish Kailasam Mani *Membrane Mechanics and Dynamics of Intracellular Signalling Laboratory, Institut Curie-Centre de Recherche, PSL Research University, Paris, France.
Nicolas Tardif *Membrane Mechanics and Dynamics of Intracellular Signalling Laboratory, Institut Curie-Centre de Recherche, PSL Research University, Paris, France.
Olivier Rossier *Interdisciplinary Institute for Neuroscience, University of Bordeaux, Bordeaux, France.ORCID http://orcid.org/0000-0002-6932-931X
Ismail M KhaterSchool of Computing Science, Simon Fraser University, Burnaby, British Columbia, Canada.
Xuesi ZhouInterdisciplinary Institute for Neuroscience, University of Bordeaux, Bordeaux, France.
Victor BretonMembrane Mechanics and Dynamics of Intracellular Signalling Laboratory, Institut Curie-Centre de Recherche, PSL Research University, Paris, France.ORCID http://orcid.org/0000-0003-4433-5665
Filipe Nunes VicenteInterdisciplinary Institute for Neuroscience, University of Bordeaux, Bordeaux, France.ORCID http://orcid.org/0000-0001-5107-0461
Adiyodi Veettil RadhakrishnanInterdisciplinary Institute for Neuroscience, University of Bordeaux, Bordeaux, France.
Céline GraciaMembrane Mechanics and Dynamics of Intracellular Signalling Laboratory, Institut Curie-Centre de Recherche, PSL Research University, Paris, France.ORCID http://orcid.org/0000-0002-3312-6465
Pamela Gonzalez TroncosoMembrane Mechanics and Dynamics of Intracellular Signalling Laboratory, Institut Curie-Centre de Recherche, PSL Research University, Paris, France.
Isabel BritoInstitut Curie, PSL University, INSERM U900, Mines Paris Tech, Paris, France.
Richard RuezMembrane Mechanics and Dynamics of Intracellular Signalling Laboratory, Institut Curie-Centre de Recherche, PSL Research University, Paris, France.
Melissa DewulfMembrane Mechanics and Dynamics of Intracellular Signalling Laboratory, Institut Curie-Centre de Recherche, PSL Research University, Paris, France.
Ghassan HamarnehSchool of Computing Science, Simon Fraser University, Burnaby, British Columbia, Canada.ORCID http://orcid.org/0000-0001-5040-7448
Ivan Robert NabiDepartment of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, Canada.ORCID http://orcid.org/0000-0002-0670-0513
Philippe CuniasseInstitute for Integrative Biology of the Cell (I2BC), Université Paris-Saclay, CEA, CNRS, Gif-sur-Yvette, France.
Pierre SensInstitut Curie, PSL Research University, Sorbonne University, CNRS UMR168, Paris, France.ORCID http://orcid.org/0000-0003-4523-3791
Grégory GiannoneInterdisciplinary Institute for Neuroscience, University of Bordeaux, Bordeaux, France.ORCID http://orcid.org/0000-0002-0932-1690
Cédric M BlouinMembrane Mechanics and Dynamics of Intracellular Signalling Laboratory, Institut Curie-Centre de Recherche, PSL Research University, Paris, France. cedric.blouin@curie.fr.ORCID http://orcid.org/0000-0003-0800-0948
Christophe LamazeMembrane Mechanics and Dynamics of Intracellular Signalling Laboratory, Institut Curie-Centre de Recherche, PSL Research University, Paris, France. christophe.lamaze@curie.fr.ORCID http://orcid.org/0000-0001-5430-2707

Funding

Agence Nationale de la Recherche (French National Research Agency) ANR-19-CE15-0020-02Agence Nationale de la Recherche (French National Research Agency) ANR-20-CE42-0003-02Agence Nationale de la Recherche (French National Research Agency) ANR-21-CE11-0004-01Association Française contre les Myopathies (French Association against Muscular Dystrophies) CAV-MUTFondation de France WB-2024-54138Institut National Du Cancer (French National Cancer Institute) AAP PLBIO no. 2020-109
6 · The paper itself

Abstract

Caveolae are invaginated plasma membrane nanodomains traditionally associated with membrane trafficking and signalling. These multifunctional organelles are also essential mechanosensors mediating the cell response to mechanical stress. We investigated the role of caveolae mechanics in regulating various signalling pathways. Single-molecule imaging and super-resolution microscopy revealed that mechanical stress rapidly triggers caveolae disassembly and the release of caveolin-1 scaffolds, which then exhibit enhanced diffusion at the plasma membrane. This promoted direct interaction between the caveolin-1 scaffolding domain and the tyrosine kinase JAK1, leading to the inhibition of its catalytic activity. A similar process was observed for eNOS, PTEN and PTP1B. The control of signalling by diffusing Cav1 scaffolds was further validated by a theoretical model based on caveolae thermodynamics. These findings establish a mechanotransduction paradigm in which signalling information is decoded remotely from the initial mechanosensing caveola, through dynamic and reversible assembly of tension-controlled complexes between signalling effectors and caveolin-1 scaffolds.

Indexed as

CaveolaeCaveolin 1Mechanotransduction, CellularAnimalsCell MembraneDiffusionHumansNitric Oxide Synthase Type IIIProtein Tyrosine Phosphatase, Non-Receptor Type 1PTEN PhosphohydrolaseStress, MechanicalCaveolin 1Nitric Oxide Synthase Type IIIProtein Tyrosine Phosphatase, Non-Receptor Type 1PTEN Phosphohydrolase

Identifiers

PMID42225832

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.