Evidence map›Paper›PMID 42225879›Full record

ArticleScientific reports2026

Long-term hyperglycaemia induces qualitative and quantitative changes in rat ultrasonic vocalizations.

Justine Renaud, Jimmy Beaulieu, Jacopo Marongiu, Giulia Costa, Maria-Grazia Martinoli, Nicola Simola

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Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Justine RenaudCellular Neurobiology, Department of Medical Biology, Université du Québec, Trois-Rivières, Québec, Canada.
Jimmy BeaulieuCellular Neurobiology, Department of Medical Biology, Université du Québec, Trois-Rivières, Québec, Canada.
Jacopo MarongiuDepartment of Biomedical Sciences, University of Cagliari, Monserrato University Campus, Monserrato, Italy.
Giulia CostaDepartment of Biomedical Sciences, University of Cagliari, Monserrato University Campus, Monserrato, Italy.
Maria-Grazia MartinoliCellular Neurobiology, Department of Medical Biology, Université du Québec, Trois-Rivières, Québec, Canada.
Nicola SimolaCellular Neurobiology, Department of Medical Biology, Université du Québec, Trois-Rivières, Québec, Canada. nicola.simola@unica.it.

Funding

Natural Sciences and Engineering Research Council of Canada 04321
6 · The paper itself

Abstract

Diabetes mellitus (DM) is currently considered a global epidemic. Recently, the relation between diabetes and mood disorders has been established, as well as a link with altered behavioural traits, that may depend on changes in the emotional state. To further elucidate the interplay between DM and changes in the emotional state, we evaluated in long-term diabetic hyperglycaemic (HG) or in control (CTRL) male rats the emission of ultrasonic vocalizations (USVs), a behavioural marker that may express the emotional states of rats and their changes. Rats were exposed to a conspecific matched for condition (i.e. HG or CTRL), to elicit calling behaviour; then, the numbers and acoustic parameters (duration, maximum frequency, minimum frequency, bandwidth) were scored for the 50-kHz USVs (appetitive) and 22-kHz USVs (aversive) emitted. Dyads of HG rats emitted higher numbers of 50-kHz USVs, compared with dyads of CTRL rats. Moreover, differences in acoustic parameters were detected between the 50-kHz USVs emitted by HG and CTRL rats. These effects were observed for the total 50-kHz USVs emitted, as well as for the flat and frequency modulated categories of 50-kHz calls. Finally, HG rats (30% of dyads) but not CTRL rats also emitted 22-kHz USVs. These findings demonstrate that long-term diabetic hyperglycaemia causes qualitative and quantitative changes in ultrasonic calling behaviour in male rats. Moreover, they suggest that measuring the emission of USVs may become an informative approach to study the effects of hyperglycaemia in rat models of DM.

Indexed as

Diabetes Mellitus, ExperimentalHyperglycemiaVocalization, AnimalAnimalsMaleRatsRats, WistarUltrasonics22-kHz calls50-kHz callsAffectAversionFlat callsFrequency modulated callsReward

Identifiers

PMID42225879
PMCPMC13458080

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.