Evidence map›Paper›PMID 42225960›Full record

Trial reportCanadian journal of anaesthesia = Journal canadien d'anesthesie2026

Comparison of different weight-based scalars of remimazolam for anesthesia induction in patients with obesity: a randomized controlled trial.

Wenwen Ni, Jiali Jiao, Ji'e Jia, Mannan Abdul, Ziyang Jiang, Lili Feng, Yan Zhuang, Yirong Cai, Wenxian Li, Yuan Han and 1 more

Abstract readRandomized Controlled TrialComparative Study
PubMed Publisher
In one paragraph

Trial report in Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Wenwen Ni *Department of Anesthesiology, Eye and Ear, Nose, and Throat (ENT) Hospital, Fudan University, Shanghai, China.
Jiali Jiao *Centre for Biomedical Data Science, Institute of Translational Medicine, Shanghai Jiao Tong University, Shanghai, China.
Ji'e JiaDepartment of Anesthesiology, Eye and Ear, Nose, and Throat (ENT) Hospital, Fudan University, Shanghai, China.
Mannan AbdulDepartment of Anesthesiology, Eye and Ear, Nose, and Throat (ENT) Hospital, Fudan University, Shanghai, China.
Ziyang JiangDepartment of Anesthesiology, Eye and Ear, Nose, and Throat (ENT) Hospital, Fudan University, Shanghai, China.
Lili FengDepartment of Anesthesiology, Eye and Ear, Nose, and Throat (ENT) Hospital, Fudan University, Shanghai, China.
Yan ZhuangDepartment of Anesthesiology, Eye and Ear, Nose, and Throat (ENT) Hospital, Fudan University, Shanghai, China.
Yirong CaiDepartment of Anesthesiology, Eye and Ear, Nose, and Throat (ENT) Hospital, Fudan University, Shanghai, China.
Wenxian LiDepartment of Anesthesiology, Eye and Ear, Nose, and Throat (ENT) Hospital, Fudan University, Shanghai, China.
Yuan HanDepartment of Anesthesiology, Eye and Ear, Nose, and Throat (ENT) Hospital, Fudan University, Shanghai, China.
Shuangshuang LiDepartment of Anesthesiology, Eye and Ear, Nose, and Throat (ENT) Hospital, Fudan University, Shanghai, China. lishuangshuang@eentanesthesia.com.

Funding

National Health Commission of the People's Republic of China RCLX2315001National Natural Science Foundation of China 82171264Natural Science Foundation of Jilin Province 82271295Natural Science Foundation of Shanghai Municipality 23ZR1409300Shanghai Medical College, Fudan University FDYXYBJ-20222004Shanghai Municipal Health Commission 202240315
6 · The paper itself

Abstract

purposePatients with obesity pose unique anesthetic challenges. Remimazolam, a short-acting benzodiazepine, is useful for induction and maintenance of general anesthesia, and its pharmacokinetic profile renders it a valuable alternative to traditional anesthetic agents in this population. We aimed to compare its induction doses based on total body weight (TBW) vs lean body weight (LBW) in patients with obesity.

methodsWe conducted a prospective, single-centre, randomized controlled trial between February 2022 and June 2023 at the Eye and Ear, Nose, and Throat (ENT) Hospital of Fudan University (Shanghai, China). We randomized 40 patients with obesity 1:1 to receive remimazolam (12 mg·kg

resultsOverall, 60 patients were enrolled. The mean (standard deviation [SD]) induction dose of remimazolam was 0.47 (0.11) mg·kg

conclusionsAt 12 mg·kg STUDY REGISTRATION: www.ChiCTR.org.cn ( ChiCTR2200056641 ); first posted 9 February 2022.

Indexed as

Anesthesia, GeneralBenzodiazepinesBody WeightHypnotics and SedativesObesityAdultDose-Response Relationship, DrugFemaleHumansMaleMiddle AgedProspective StudiesBenzodiazepinesHypnotics and Sedativesremimazolamgeneral anesthesiainduction doseobesityremimazolamweight-based scalar

Identifiers

PMID42225960

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.