Evidence map›Paper›PMID 42225967›Full record

ArticleLeukemia2026

TP53 deficiency in AML induces resistance to T-cell engagers through an immunosuppressive secretome.

Lis Winter, Lea Pawlowsky, Amelie Muth, Anne-Sophie Neumann, Kieron White, Maryam Kazerani, Daniel Nixdorf, Bettina Brauchle, Lisa Rohrbacher, Gerulf Hänel and 13 more

Abstract read
In one paragraph

Article in Leukemia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Lis WinterLaboratory for Translational Cancer Immunology, Gene Center, LMU Munich, Munich, Germany.ORCID http://orcid.org/0000-0002-2537-4848
Lea PawlowskyLaboratory for Translational Cancer Immunology, Gene Center, LMU Munich, Munich, Germany.
Amelie MuthLaboratory for Translational Cancer Immunology, Gene Center, LMU Munich, Munich, Germany.ORCID http://orcid.org/0009-0009-6900-7212
Anne-Sophie NeumannLaboratory for Translational Cancer Immunology, Gene Center, LMU Munich, Munich, Germany.ORCID http://orcid.org/0009-0004-5576-6983
Kieron WhiteLaboratory for Translational Cancer Immunology, Gene Center, LMU Munich, Munich, Germany.
Maryam KazeraniLaboratory for Translational Cancer Immunology, Gene Center, LMU Munich, Munich, Germany.ORCID http://orcid.org/0000-0002-5803-4807
Daniel NixdorfLaboratory for Translational Cancer Immunology, Gene Center, LMU Munich, Munich, Germany.ORCID http://orcid.org/0000-0003-1612-9952
Bettina BrauchleLaboratory for Translational Cancer Immunology, Gene Center, LMU Munich, Munich, Germany.
Lisa RohrbacherLaboratory for Translational Cancer Immunology, Gene Center, LMU Munich, Munich, Germany.
Gerulf HänelLaboratory for Translational Cancer Immunology, Gene Center, LMU Munich, Munich, Germany.ORCID http://orcid.org/0000-0003-4685-6499
Agnese PetreraMetabolomics and Proteomics Core, Helmholtz Zentrum München, Germany; Research Center for Environmental Health (GmbH), Neuherberg, Germany.
Eva BriemAnthropology and Human Genomics, Faculty of Biology, LMU Munich, Munich, Germany.
Gordon V HoffmannDivision of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany.
Thomas JanertDivision of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany.
Emanuele CarliniDivision of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany.
Adrian GottschlichDepartment of Medicine III, LMU University Hospital, LMU Munich, Munich, Germany.ORCID http://orcid.org/0000-0002-2898-4182
Karsten SpiekermannDepartment of Medicine III, LMU University Hospital, LMU Munich, Munich, Germany.ORCID http://orcid.org/0000-0002-5139-4957
Tobias StraubBioinformatics Unit, Biomedical Center, LMU Munich, Martinsried, Germany.
Roman KischelAmgen Research (Munich) GmbH, Munich, Germany.
Sebastian KoboldDivision of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany.ORCID http://orcid.org/0000-0002-5612-4673
Michael AndreeffDepartment of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID http://orcid.org/0000-0002-1144-1958
Veit L BueckleinLaboratory for Translational Cancer Immunology, Gene Center, LMU Munich, Munich, Germany.ORCID http://orcid.org/0000-0001-7391-7280
Marion SubkleweLaboratory for Translational Cancer Immunology, Gene Center, LMU Munich, Munich, Germany. Marion.Subklewe@med.uni-muenchen.de.ORCID http://orcid.org/0000-0001-9154-9469

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bispecific T-cell engagers (BiTE

Indexed as

Leukemia, Myeloid, AcuteT-LymphocytesTumor Suppressor Protein p53Cell ProliferationCoculture TechniquesHumansTP53 protein, humanTumor Suppressor Protein p53

Identifiers

PMID42225967
PMCPMC13421328

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.