Observational studyCritical care (London, England)2026
Predictive validity of daily sequential organ failure assessment (SOFA)-2 score for 30-day mortality.
Observational study in Critical care (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Prognostic significance of the blood urea nitrogen-to-serum albumin ratio in patients with septic shock.Experimental and therapeutic medicine · 2026Article
- Association of Lok index with all-cause mortality among critically ill patients suffering from coronary artery disease: a cohort study based on MIMIC database.BMC cardiovascular disorders · 2026Article
- Predictive validity of SOFA-2: analytical and contextual considerations.Critical care (London, England) · 2026Article
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5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe sequential organ failure assessment (SOFA) score was recently updated to better reflect contemporary intensive care. This study compares the predictive validity of the updated SOFA-2 and the previous SOFA-1 for 30-day mortality over the first week in ICU, overall and in subgroups with distinct age and comorbidity profiles.
methodsWe conducted a retrospective observational study of adult patients admitted to four ICUs in Sweden from 2010 to 2021. Predictive validity for 30-day mortality was assessed on day 1-7 using the area under the receiver operating characteristic curve (AUROC).
resultsWe included 29,820 admissions (mean age 60 years, 64.8% males, median Charlson comorbidity index [CCI] 1). Reclassification between SOFA-1 and SOFA-2 occurred in 75-79% of admissions across days 1-7. On day 1, the AUROC for 30-day mortality was 0.81 (95% CI 0.80-0.81) for SOFA-2 and 0.80 (95% CI 0.79-0.81) for SOFA-1 (p < 0.001). From day 2 onward, AUROCs declined for both scores and were largely similar. Among trauma patients (mean age 50 years; median CCI 0), day-1 AUROC for SOFA-2 was 0.81 (95% CI 0.79-0.83), while among sepsis patients (mean age 61 years; median CCI 3) it was 0.72 (95% CI 0.70-0.74), with comparable performance for SOFA-1.
conclusionsSOFA-2 provided modestly better discrimination for 30-day mortality on ICU-day 1 compared with SOFA-1. Predictive validity diminished over subsequent days for both scores and varied across subgroups with different age and comorbidity distributions, underscoring the context-dependence of organ dysfunction scoring.
trial registrationhttps://doi.org/10.5281/zenodo.17651826 , registration date November 19, 2025.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.