Evidence mapPaperPMID 42226292Full record

ArticleJournal of translational medicine2026

FTO-modulated m

Chenyu Lin, Chenyang Cao, Shujing Cui, Jinyi Guo, Yu Xin, Jun Shao

Abstract read
In one paragraph

Article in Journal of translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chenyu Lin *Department of Ophthalmology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, Jiangsu, 214023, China.
Chenyang Cao *Department of Ophthalmology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, Jiangsu, 214023, China.
Shujing CuiThe Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, National Engineering Research Center for Cereal Fermentation and Food Bio Manufacturing, Jiangnan University, Wuxi, Jiangsu, 214122, China.
Jinyi GuoThe Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, National Engineering Research Center for Cereal Fermentation and Food Bio Manufacturing, Jiangnan University, Wuxi, Jiangsu, 214122, China.
Yu XinThe Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, National Engineering Research Center for Cereal Fermentation and Food Bio Manufacturing, Jiangnan University, Wuxi, Jiangsu, 214122, China. yuxin@jiangnan.edu.cn.
Jun ShaoDepartment of Ophthalmology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, Jiangsu, 214023, China. shaojun@njmu.edu.cn.ORCID http://orcid.org/0000-0003-3477-4568

Funding

China Postdoctoral Science Foundation 2020M671541Top Talent Support Program for Young and Middle-aged People of Wuxi Health Committee BJ2023017
6 · The paper itself

Abstract

backgroundThe N6-methyladenosine (m

methodsMethylated RNA immunoprecipitation sequencing (MeRIP-Seq) was used to screen abnormal m

resultsMeRIP-Seq and RIP-RT-qPCR indicated that KIF11 should be a downstream target of FTO. Regarding qRT-PCR and MeRIP-qRT-PCR, in vitreous body samples from patients with PDR and hRECs under hyperglycemic conditions, expressed enhanced levels of FTO and KIF11, whereas the m

conclusionOur findings demonstrated that the m

Indexed as

AdenosineAlpha-Ketoglutarate-Dependent Dioxygenase FTODemethylationDiabetic RetinopathyKinesinsMicrovesselsRetinaRetinal VesselsUp-RegulationAnimalsCell MovementCell ProliferationDiabetes Mellitus, ExperimentalEndothelial CellsEpitranscriptomeHumansAdenosineAlpha-Ketoglutarate-Dependent Dioxygenase FTOKinesinsN-methyladenosineRNA, MessengerDemethylationDiabetic retinopathyFTOKIF11Retinal microvascular dysfunction

Identifiers

PMID42226292
PMCPMC13439988

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.