ArticlePest management science2026
Design, synthesis, antibacterial activity, and mechanism study of phosphate-containing vanillin sulfonylhydrazide derivatives.
Article in Pest management science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
backgroundThe increasing prevalence of phytopathogenic bacteria, such as Xanthomonas oryzae pv. oryzicola (Xoc), Xanthomonas axonopodis pv. citri (Xac) and Pseudomonas syringae pv. actinidiae (Psa), poses a serious threat to global agricultural productivity, underscoring the urgent need for novel antibacterial agents with distinct mechanisms of action. This study designed, synthesized, and evaluated a series of phosphonyl-substituted vanillyl sulfonyl hydrazide derivatives for their antibacterial activity and to elucidate the potential mechanisms of action of the most active compound.
resultsIn total, 26 novel phosphonyl-substituted vanillyl sulfonyl hydrazide derivatives C were synthesized and structurally confirmed. Bioassays revealed that most compounds exhibited moderate to good antibacterial activity against the tested pathogens. Notably, compound C02 exhibited the most potent activity against Xoc, with a half-maximal effective concentration (EC
conclusionCompound C02 exerts its potent antibacterial effects through a multi-mechanism action involving membrane disruption and interference with multiple core metabolic processes. These findings provide a theoretical foundation and experimental evidence for developing novel antibacterial agents based on the phosphate-containing vanillin sulfonyl hydrazide scaffold, significantly advancing the field by identifying a promising lead compound with a well-characterized, multi-faceted mode of action. © 2026 Society of Chemical Industry.
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