A Self-Cascading Immunomodulatory Hydrogel for Remodeling Infected Diabetic Wounds.

Yulong Lan, Xiaoliang Qi, Jing Chen, Lifeng Tan, Jianliang Shen

Abstract read

In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yulong LanCollege of Chemistry, Xiangtan University, Xiangtan, China.

Xiaoliang QiZhejiang Key Laboratory of Ophthalmic Drug Discovery and Medical Device Research, Eye Hospital, Wenzhou Medical University, Wenzhou, China.ORCID https://orcid.org/0000-0002-2480-7242

Jing ChenThe Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, China.

Lifeng TanCollege of Chemistry, Xiangtan University, Xiangtan, China.ORCID https://orcid.org/0000-0003-3882-9976

Jianliang ShenZhejiang Key Laboratory of Ophthalmic Drug Discovery and Medical Device Research, Eye Hospital, Wenzhou Medical University, Wenzhou, China.ORCID https://orcid.org/0000-0003-4351-4872

Funding

National Natural Science Foundation of China 22377102National Natural Science Foundation of China 32501180Zhejiang Provincial Natural Science Foundation LR23C100001

6 · The paper itself

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA)-infected diabetic foot ulcers (DFUs) remain refractory to healing owing to persistent inflammation, hyperglycemia, and impaired tissue regeneration. Current antimicrobial strategies primarily eliminate viable bacteria but overlook pathogen-associated molecular patterns (PAMPs) released upon bacterial death, which sustain NF-κB/NLRP3 activation and prevent immune resolution. However, suppressing microbial burden without neutralizing PAMP-driven inflammation fails to restore the regenerative wound microenvironment. Here, we report a self-cascading hypoglycemic immunomodulatory hydrogel integrating Fe

Indexed as

HydrogelsImmunologic FactorsWound HealingAnimalsAnti-Bacterial AgentsBoronic AcidsFibroinsHyaluronic AcidMacrophagesMethicillin-Resistant Staphylococcus aureusMiceAnti-Bacterial Agentsbenzeneboronic acidBoronic AcidsFibroinsHyaluronic AcidHydrogelsImmunologic Factorsdiabetic wound healingimmune microenvironment remodelingmethicillin‐resistant Staphylococcus aureuspathogen‐associated molecular patternsself‐cascading hydrogel

Identifiers

PMID42226495

DOI10.1002/adma.73560

PMCPMC13351791

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.