Evidence map›Paper›PMID 42226594›Full record

ArticleNanomedicine (London, England)2026

A Phase I trial of PLZ4-coated paclitaxel-loaded micelles in patients with refractory non-muscle-invasive bladder cancer.

Athira Narayan, Ryan C Leibrandt, Joyce S Lee, Marc A Dall'Era, Jared M Whitson, Thenappan Chandrasekar, Avery Braun, Matthew Mossanen, Hong Li, Primo N Lara and 3 more

Registry-linked trialAbstract read
In one paragraph

Article in Nanomedicine (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06173349 (A Phase I Microtrial With PLZ4-Coated Paclitaxel-Loaded Micelles), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06173349 phase1recruitingnot on this map

A Phase I Microtrial With PLZ4-Coated Paclitaxel-Loaded Micelles (PPM) in Patients With Recurrent or Refractory Non-Myoinvasive Bladder Cancer

TypeinterventionalSponsorUniversity of California, DavisRan2023 to 2027Enrolled12ConditionsRecurrent Non-Muscle Invasive Bladder Carcinoma, Stage 0a Bladder Cancer AJCC v8, Stage 0is Bladder Cancer AJCC v8, Stage I Bladder Cancer AJCC v8ArmsPLZ4-coated paclitaxel loaded micelles (PPM)
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Athira NarayanDepartment of Internal Medicine, University of California Davis School of Medicine, Sacramento, CA, USA.ORCID 0000-0002-9406-7294
Ryan C LeibrandtDepartment of Internal Medicine, Division of Hematology Oncology, UC Davis Comprehensive Cancer Center, University of California Davis School of Medicine, Sacramento, CA, USA.ORCID 0000-0002-4056-9651
Joyce S LeeDepartment of Pharmacy Services, University of California Davis Health System, Sacramento, CA, USA.
Marc A Dall'EraDepartment of Urology, University of California Davis School of Medicine, Sacramento, CA, USA.ORCID 0000-0002-2301-2683
Jared M WhitsonDepartment of Urology, University of California Davis School of Medicine, Sacramento, CA, USA.ORCID 0009-0000-0417-5957
Thenappan ChandrasekarDepartment of Urology, University of California Davis School of Medicine, Sacramento, CA, USA.ORCID 0000-0002-2173-5028
Avery BraunDepartment of Urology, University of California Davis School of Medicine, Sacramento, CA, USA.ORCID 0000-0003-4516-9646
Matthew MossanenDepartment of Medicine, Brigham and Women's Hospital and Boston VA, West Roxbury, MA, USA.ORCID 0000-0001-5444-2515
Hong LiDepartment of Internal Medicine, Division of Hematology Oncology, UC Davis Comprehensive Cancer Center, University of California Davis School of Medicine, Sacramento, CA, USA.
Primo N LaraDepartment of Internal Medicine, Division of Hematology Oncology, UC Davis Comprehensive Cancer Center, University of California Davis School of Medicine, Sacramento, CA, USA.ORCID 0000-0001-9512-0002
Kit S LamDepartment of Biochemistry and Molecular Medicine, University of California School of Medicine, Sacramento, CA, USA.ORCID 0000-0002-3076-6969
Chong-Xian PanDepartment of Medicine, Brigham and Women's Hospital and Boston VA, West Roxbury, MA, USA.ORCID 0000-0002-8588-3994
Mamta ParikhDepartment of Internal Medicine, Division of Hematology Oncology, UC Davis Comprehensive Cancer Center, University of California Davis School of Medicine, Sacramento, CA, USA.ORCID 0000-0002-7300-7452

Funding

Staff InvestigatorsP30CA093373 · NCI · UNIVERSITY OF CALIFORNIA DAVIS · PI KC KENT LLOYD · 2002 to 2026
$84.9M
BLRD VA I01 BX001784CSRD VA I01 CX002247NCI NIH HHS P30 CA093373
6 · The paper itself

Abstract

CLINICAL

trial registrationNCT06173349.

Indexed as

Antineoplastic Agents, PhytogenicNon-Muscle Invasive Bladder NeoplasmsPaclitaxelUrinary Bladder NeoplasmsHumansMicellesAntineoplastic Agents, PhytogenicMicellesPaclitaxelbladder cancerintravesicalMicellestargetedtaxane

Identifiers

PMID42226594
PMCPMC13285637

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.