Evidence map›Paper›PMID 42226681›Full record

ArticleJournal of clinical laboratory analysis2026

Age-Associated Variations in Complete Blood Cell Count Parameters and Derived Indices Among Community-Dwelling Chinese Older Adults.

Xiangyi Ma, Na Liu, Xiang Wu, Qiudan Chen, Xiaotong Chen, Qingyu Zhou, Shuying Chen, Yong Lin, Xuefeng Wang

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In one paragraph

Article in Journal of clinical laboratory analysis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Xiangyi MaDepartment of Clinical Laboratory, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.ORCID https://orcid.org/0009-0001-6783-868X
Na LiuCollege of Medical Imaging and Laboratory, Jining Medical University, Jining, China.
Xiang WuDepartment of Laboratory Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Qiudan ChenDepartment of Clinical Laboratory, Jing'an District Centre Hospital, Fudan University, Shanghai, China.
Xiaotong ChenDepartment of Clinical Laboratory, Jing'an District Centre Hospital, Fudan University, Shanghai, China.
Qingyu ZhouDepartment of Clinical Laboratory, Jing'an District Centre Hospital, Fudan University, Shanghai, China.
Shuying ChenDepartment of Laboratory Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Yong LinDepartment of Clinical Laboratory, Jing'an District Centre Hospital, Fudan University, Shanghai, China.
Xuefeng WangDepartment of Clinical Laboratory, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.ORCID https://orcid.org/0000-0001-9609-4117

Funding

National Key Research and Development Plan of China 2018YFC2000200; Y.L.Shanghai Municipal Health Commission GWVI-11.1-27; Y.L.
6 · The paper itself

Abstract

backgroundThis study aims to systematically characterize the physiological trajectories of complete blood cell count (CBC) parameters and their derived inflammatory indicators with age, providing high-quality evidence for assessing immunosenescence and the health of the elderly.

methodsThis cross-sectional study initially recruited 9331 participants aged 24-97 years. After applying exclusion criteria, 1630 healthy individuals were included for analysis. Data are presented as median (2.5th-97.5th percentiles). The Kruskal-Wallis test followed by Dunn's test with Bonferroni correction was used to compare CBC parameters and their derived indicators among four age groups within each sex. The Mann-Whitney U test was used to compare differences between males and females within each age group.

resultsRed blood cell (RBC), hemoglobin (HGB), hematocrit (HCT), and mean corpuscular hemoglobin concentration (MCHC) decreased with age, while mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), and red blood cell distribution width (RDW-CV) increased; sex-specific differences persisted in most parameters. Monocyte percentage and absolute count gradually increased with age; other white blood cell differentials showed variable patterns. Among CBC derived indicators: PLR and SII decreased with age; MLR remained low with limited variability in males; NLR exhibited a fluctuating trend across age groups. Platelet (PLT) progressively decreased with age.

conclusionThe comprehensive dataset generated in this study has allowed observation of dynamic profiles of CBC parameters and their derived indicators in the healthy elderly population. This provides scientific evidence and theoretical support for aging and health assessment as well as chronic disease management among older adults.

Indexed as

AgingBlood Cell CountAdultAgedAged, 80 and overAge FactorsChinaCross-Sectional StudiesEast Asian PeopleFemaleHumansMaleMiddle AgedYoung AdultagingCBC parametersderived inflammatory indicatorshigh‐quality evidencetrend

Identifiers

PMID42226681
PMCPMC13399603

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.