Trial reportDrug design, development and therapy2026
Preoperative Stellate Ganglion Block for Postoperative Sore Throat in Patients Undergoing Double-Lumen Endotracheal Intubation: A Randomized Clinical Trial.
Trial report in Drug design, development and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
12 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background: As a common complication of double-lumen endobronchial tube (DLT) intubation during thoracic surgery, postoperative sore throat (POST) brings adverse impacts on patient recovery. Although stellate ganglion block (SGB) can modulate sympathetic tone and inflammatory reactions, its efficacy in preventing DLT-related POST is still inconclusive. This trial aimed to determine whether SGB reduces the incidence of POST at 6 h after surgery in patients undergoing DLT intubation. Methods: In this single-center prospective randomized controlled trial, 124 patients undergoing elective thoracic surgery with left-sided DLT intubation were randomized 1:1 to two groups: the intervention group received preoperative ultrasound-guided right-sided SGB (5 mL of 0.5% ropivacaine), and the control group received standard care (ultrasound scanning without injection plus 1% tetracaine gel lubrication). The primary endpoint was the incidence of POST at 6 h after surgery. Results: Of the 124 randomized patients, 111 eligible subjects were finally included in the full analysis. The incidence of POST at 6 h after surgery, was significantly decreased in the ultrasound-guided SGB intervention group compared with the standard care control group (14.3% vs 38.2%; RR = 0.37; 95% CI: 0.18-0.77; Conclusion: Preoperative ropivacaine-based SGB could reduce the incidence and severity of POST in patients for DLTs in thoracic surgery, with this protective effect persisting for at least 24 h after surgery. These preliminary results require validation in larger multicenter studies. Clinical Trial Registration: Chinese Clinical Trial Registry, ChiCTR2400092313.
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