ArticleDrug design, development and therapy2026
Pharmacokinetics and Pharmacodynamics of Dapagliflozin in Obese and Nonobese Healthy Adults Following Multiple Administration.
Article in Drug design, development and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Dapagliflozin, a sodium-glucose cotransporter 2 inhibitor, lowers blood glucose levels by preventing renal glucose reabsorption, resulting in urinary glucose excretion. Because dapagliflozin-induced glycosuria produces a modest reduction in body weight, it may benefit patients with type 2 diabetes who are overweight or obese. Pathophysiologic alterations associated with obesity may lead to clinically significant differences in drug pharmacokinetic (PK) and pharmacodynamic (PD) properties. Purpose: This study aimed to evaluate the PK and PD characteristics of dapagliflozin in obese and nonobese healthy adults and assess the effect of obesity on these profiles by comparing outcomes between the two groups following multiple oral doses. Methods: In this open-label, multiple-dose study, dapagliflozin 10 mg tablets were administered once daily for 5 days to healthy adults. Serial blood samples for PK analysis were collected before and up to 48 h after the last dose on day 5. PK parameters were determined using noncompartmental analysis.Sensitivity analyses were conducted, including correlation analysis of PK parameters with weight or BMI using Pearson's correlation coefficients ( Results: Thirteen nonobese and nine obese participants completed the study. The geometric mean ratio (obese/nonobese) (90% CIs) of the area under the plasma concentration-time curve during a dosing interval at steady state (AUC Conclusion: The AUC
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