Evidence map›Paper›PMID 42226771›Full record

ArticlePeerJ2026

IL-8 is a potential biomarker for retinal detachment secondary to choroidal melanoma.

Zhen Xing, Xinran Zhang, Wei Yu, Yingqing Lei, Guiqu Wang, Hongbin Lv

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zhen Xing *Department of Ophthalmology, The Affiliated Hospital of Southwest Medical University, Sichuan, China.
Xinran Zhang *Department of Ophthalmology, The Affiliated Hospital of Southwest Medical University, Sichuan, China.
Wei YuDepartment of Ophthalmology, The Affiliated Hospital of Southwest Medical University, Sichuan, China.
Yingqing LeiDepartment of Ophthalmology, The Affiliated Hospital of Southwest Medical University, Sichuan, China.
Guiqu WangDepartment of Ophthalmology, The Affiliated Hospital of Southwest Medical University, Sichuan, China.
Hongbin LvDepartment of Ophthalmology, The Affiliated Hospital of Southwest Medical University, Sichuan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aims to identify potential biomarkers for retinal detachment secondary to choroidal melanoma (CM). Mendelian randomisation (MR) analysis, immunohistochemistry, cell proliferation and migration assays, co-culture experiments involving human microglial cells (HMC3) and CM cells, and tube formation assay were employed to validate the role of IL-8 in retinal detachment secondary to choroidal melanoma. Mendelian randomisation analysis identified four inflammatory mediators causally linked to malignant melanoma progression: CDCP1 concentration (

Indexed as

Choroid NeoplasmsInterleukin-8MelanomaRetinal DetachmentBiomarkersBiomarkers, TumorCell ProliferationHumansBiomarkersBiomarkers, TumorCXCL8 protein, humanInterleukin-8Choroidal melanomaInflammatory factorsInterleukin-8Mendelian randomisationRetinal detachment

Identifiers

PMID42226771
PMCPMC13222547

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.