ArticleThe Journal of physiology2026
Neither intracellular oxygen availability nor mitochondrial coupling explain lower oxidative capacity in older human vastus lateralis muscle in vivo.
Article in The Journal of physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Skeletal muscle oxidative capacity is a useful in vivo marker of mitochondrial health and is generally lower in the knee-extensor muscles of older compared with younger adults. The causes of this lower oxidative capacity in older muscle are unclear. We used magnetic resonance spectroscopy to investigate the influence of intramyocellular oxygen availability and the coupling (P/O ratio) between mitochondrial respiration and ATP production on oxidative capacity in the knee-extensor muscles of 14 young and 10 older adults. Participants completed a 24-s contraction protocol followed by 10 min of recovery and 8 min of cuff occlusion while interleaved
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