Evidence map›Paper›PMID 42227731›Full record

ArticleThe Journal of physiology2026

Neither intracellular oxygen availability nor mitochondrial coupling explain lower oxidative capacity in older human vastus lateralis muscle in vivo.

Luke R Arieta, Zoe H Smith, Rajakumar Nagarajan, Martin Meyerspeer, Jane A Kent

Abstract read
In one paragraph

Article in The Journal of physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Luke R ArietaMuscle Physiology Laboratory, Department of Kinesiology, University of Massachusetts Amherst, Amherst, MA, USA.ORCID https://orcid.org/0000-0002-8424-9051
Zoe H SmithMuscle Physiology Laboratory, Department of Kinesiology, University of Massachusetts Amherst, Amherst, MA, USA.ORCID https://orcid.org/0000-0002-4725-0926
Rajakumar NagarajanHuman Magnetic Resonance Center, Institute for Applied Life Sciences, University of Massachusetts Amherst, Amherst, MA, USA.ORCID https://orcid.org/0000-0001-7099-2816
Martin MeyerspeerHigh Field MR Center, Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria.
Jane A KentMuscle Physiology Laboratory, Department of Kinesiology, University of Massachusetts Amherst, Amherst, MA, USA.ORCID https://orcid.org/0000-0001-5487-2849

Funding

Muscle Fatigue and Mobility Function in Aging - MR-compatible ergometerR01AG058607 · NIA · UNIVERSITY OF MASSACHUSETTS AMHERST · PI KENT, JANE A · 2019 to 2023
$2.6M
NIA NIH HHS R01 AG058607NIH HHS R01 AG058607
6 · The paper itself

Abstract

Skeletal muscle oxidative capacity is a useful in vivo marker of mitochondrial health and is generally lower in the knee-extensor muscles of older compared with younger adults. The causes of this lower oxidative capacity in older muscle are unclear. We used magnetic resonance spectroscopy to investigate the influence of intramyocellular oxygen availability and the coupling (P/O ratio) between mitochondrial respiration and ATP production on oxidative capacity in the knee-extensor muscles of 14 young and 10 older adults. Participants completed a 24-s contraction protocol followed by 10 min of recovery and 8 min of cuff occlusion while interleaved

Indexed as

AgingMitochondria, MuscleOxygenOxygen ConsumptionQuadriceps MuscleAdenosine TriphosphateAdultAgedFemaleHumansMaleYoung AdultAdenosine TriphosphateOxygenageingATPcellular respirationdeoxymyoglobinintracellular oxygen tensionknee extensorsphosphocreatine recoveryP/O ratio

Identifiers

PMID42227731
PMCPMC13370723

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.