Evidence map›Paper›PMID 42228054›Full record

ArticleCNS neuroscience & therapeutics2026

DL-3-n-Butylphthalide Protects Against PrP

Wei Wu, Xixi Zhang, Mingyue Jiang, Ning Ma

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CNS neuroscience & therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Wei WuThe Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.ORCID 0009-0008-7145-3820
Xixi ZhangDepartment of Basic Research, Guangzhou National Laboratory, Guangzhou, Guangdong, China.
Mingyue JiangDepartment of Basic Research, Guangzhou National Laboratory, Guangzhou, Guangdong, China.
Ning MaThe Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.

Funding

Basic and Applied Basic Research Foundation of Guangdong Province 2022A1515110669China Postdoctoral Science Foundation 2021M703235National Natural Science Foundation of China 82200355National Natural Science Foundation of China 82470243Research Fund of Qingyuan People's Hospital 202201-208
6 · The paper itself

Abstract

backgroundPrion diseases are fatal neurodegenerative diseases caused by misfolded prion protein. DL-3-n-butylphthalide (NBP), a synthetic agent derived from celery seeds, exhibits neuroprotective effects in multiple neurological disorders. However, its effects against prion peptide-induced neurotoxicity remain unclear.

methodsA PrP

resultsNBP attenuated PrP

conclusionNBP mitigates PrP

Indexed as

BenzofuransDynaminsGTP PhosphohydrolasesMitochondrial DynamicsNeuroprotective AgentsNF-E2-Related Factor 2Peptide FragmentsPrionsAnimalsApoptosisHumansMiceMitochondriaNeuronsOxidative StressSignal Transduction3-n-butylphthalideBenzofuransDNM1L protein, humanDnm1l protein, mouseDynaminsGTP PhosphohydrolasesNeuroprotective AgentsNfe2l2 protein, mouseNF-E2-Related Factor 2OPA1 protein, humanOpa1 protein, mousePeptide Fragmentsprion protein (106-126)PrionsDL‐3‐n‐butylphthalideDRP1mitochondrial dysfunctionNRF2OPA1oxidative stressprion diseases

Identifiers

PMID42228054
PMCPMC13240468

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.