SynthesisJournal of neurology2026
Association of combined ultra-processed food intake (ultra-processed dietary pattern) with cognitive function impairment: a meta-analysis of prospective cohort studies.
Synthesis in Journal of neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
9 authors.
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Abstract
backgroundPrevious studies on ultra-processed foods (UPF) and cognitive impairment often isolated UPF from overall dietary patterns, limiting real-world interpretation.
methodsWe systematically searched PubMed, Embase, Web of Science, and Cochrane Library up to April 2026 for prospective cohort studies assessing total UPF intake (defined by NOVA) and risk of cognitive impairment (including cognitive dysfunction, dementia, and Alzheimer's disease). A random-effects model was used to pool adjusted hazard ratios (HRs) comparing highest versus lowest UPF consumption.
resultsEight cohort studies (total > 250,000 participants) were included. High combined UPF intake was associated with a 14% higher risk of cognitive impairment (pooled HR = 1.14, 95%CI 1.04-1.25, I
conclusionHigher consumption of UPF within a ultra-processed dietary context is positively associated with cognitive impairment risk, particularly among middle-aged adults. These findings support dietary guidelines that recommend limiting UPF intake.
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