ArticleDiscover nano2026
Photophysical characterization, biocompatibility and anticancer studies of green fabricated copper doped zirconium dioxide nanoparticles derived from Clitoria ternatea.
Article in Discover nano, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
In an attempt to make the best out of waste, we have utilised shade-dried flower aqueous extract, Clitorea ternatea, to synthesise nanoparticles and apply them to the biomedical field. Cancer treatment has faced many obstacles due to resistance to chemotherapeutic drugs and radio-resistance. Alternative palliative therapy can pave the way for this limitation. Copper-doped zirconia nanoparticles were synthesised in this present study, using Clitorea ternatea flower aqueous extract, and were characterised using UV-vis spectrophotometry, dynamic light scattering, zeta potential analysis, XRD, FTIR, SEM, and EDX. The size of the nanoparticles, as revealed by SEM, was in the range of 87-150 nm, and the zeta potential was - 19 mV, showing their nano size and moderate stability, respectively. Further, the biocompatibility was assessed using in vitro cell viability and haemolysis assay. The nanoparticles were found to be biocompatible up to a dose of 50 μg/mL. These nanoparticles have also shown antioxidant activity as well as cervical cancer cell-killing activity. The IC 50 for SiHa cells was found to be 23.8 μg/mL. The outcome of this study indicated that Cu-ZrO
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